Hemodynamic Responses and Salivary Markers of the Interaction of 12 Weeks of Training With Different Anti-hypertensive in Menopausal Women
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Changes in Ambulatorial Blood Pressure
研究概览
简要总结
Different classes of antihypertensives may have different responses when associated with exercise. Thus, this study aims to compare the responses of the association of 12 weeks of aerobic exercise and weightlifting with different classes of medications in 45 postmenopausal hypertensive women.
详细描述
Cardiovascular diseases are the leading causes of death and postmenopausal women. Physical exercise, in turn, is a strategy to reduce cardiovascular stress, by decreasing the blood pressure (BP) at rest and several risk factors associated with sedentary lifestyle, thus improving the quality and life expectancy of these women. However, different classes of antihypertensives may have different responses when associated with exercise. Thus, this study aims to compare the responses of the association of 12 weeks of aerobic exercise and weightlifting with different classes of medications in 45 postmenopausal hypertensive women. The volunteers will do cardiovascular and biochemistry evaluations before and after the intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women aged between 50 and 70 years;
- •Be in the postmenopausal phase;
- •Be able to practice physical exercise on treadmill and bodybuilding,
- •Receive a release certificate for exercise practice;
- •Do not present physical problems or cardiovascular complications that prevent the performance of physical exercises;
- •In the case of hypertensives: present stage 1 hypertension, according to the guidelines of the Brazilian Society of Hypertension (2010);
- •In the case of hypertensive patients, undergo drug treatment with β-blockers or Angiotensin receptor blockers.
排除标准
- •Present history of stroke or acute myocardial infarction;
- •Present diagnosis of Diabetes Mellitus or renal pathologies;
- •Use of antihypertensive drugs from classes that were not selected for this project;
- •Make use of hormonal therapies;
- •Being uncompensated hypertensive.
研究组 & 干预措施
No medication
Group of pre-hypertensive women with no medication who practiced 12 weeks of training with Combined Exercise Training, non-obese, nonsmokers and with no characteristics that prevented them from performing the activities. In addition this group could not modify the dose or type of the medicine and should be using the same medicine and dose for at least 6 months
干预措施: Combined exercise (Other)
Angiotensin receptor blockers
Group of hypertensive women taking Angiotensin receptor blockers who practiced 12 weeks of training with Combined Exercise Training, non-obese, nonsmokers and with no characteristics that prevented them from performing the activities. In addition this group could not modify the dose or type of the medicine and should be using the same medicine and dose for at least 6 months
干预措施: Combined exercise (Other)
Beta blockers
Group of hypertensive women taking Beta blockers who practiced 12 weeks of training with Combined Exercise Training, non-obese, nonsmokers and with no characteristics that prevented them from performing the activities. In addition this group could not modify the dose or type of the medicine and should be using the same medicine and dose for at least 6 months
干预措施: Combined exercise (Other)
结局指标
主要结局
Changes in Ambulatorial Blood Pressure
时间窗: Before and within 72 hours after 12 weeks of exercise training
All volunteers were submitted to a 24-hour Blood Pressure (BP; systolic and diastolic measurements) assessment by Ambulatorial Blood Pressure Monitoring (ABPM) before and after 10 weeks of combined exercise training, with a minimum of 48 hours after the last training session. A device was used associated with a diary of examination to self-report of activities of daily living (sleep, work, food) or any event that could interfere abnormally with BP or device measurements. The device was always placed 7am and the measurements were made every 15 minutes from 7h to 23h and every 30 minutes from 23h to 7h. The monitoring was considered valid when it happened for a period of 24 hours. The following results were evaluated: systolic blood pressure; diastolic blood pressure, mean blood pressure and heart rate in awake, sleep and 24-hour periods. Before the use ABPM during daily activities, resting blood pressure were measured using the same equipment after 15 min of rest in siting position.
次要结局
- Changes of Biochemical markers on blood(Before and within 72 hours after 12 weeks of exercise training)
- Changes in salivary oxidative stress(Before and within 72 hours after 12 weeks of exercise training)
- Changes in Ambulatorial Blood Pressure Variability(Before and within 72 hours after 12 weeks of exercise training)
- Changes of blood pressure reactivity(Before and within 72 hours after 12 weeks of exercise training)
- Changes in Heart Rate Variability(Before and within 72 hours after 12 weeks of exercise training)
研究者
Igor Moraes Mariano
Bachelor
Federal University of Uberlandia