REDUCING BLOOD LOSS DURING ABDOMINAL MYOMECTOMY: SUBLINGUAL MISOPROSTOL WITH PERICERVICAL TOURNIQUET VERSUS PERICERVICAL TOURNIQUET ALONE; A RANDOMIZED CONTROL TRIA

Not Applicable

• Conditions: Surgery; UTERINE FIBROIDS

• Registration Number: PACTR202103517062817
• Lead Sponsor: Adebayo M.D. Agboola

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-03-12
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 68

Inclusion Criteria

1.Patients presenting for abdominal myomectomy with documented uterine fibroids on pelvic imaging.
2.Age > 18years.
3.Pre-menopausal women
4.Pre-operative hematocrit >30%
5.Women willing to have sublingual administration of misoprostol or a placebo pre-procedure.
6.No other pre-operative medical intervention to reduce blood loss during abdominal myomectomy.
7.Consultant-led Abdominal myomectomy.
8.Regional anaesthesia for Abdominal myomectomy
9.Ability to understand and the willingness to sign a written informed consent.

Exclusion Criteria

1.Patients who have had a prior abdominal myomectomy
2.Post-menopausal women
3.Patients with a history of gynecologic malignancy
4.Patients with known bleeding/clotting disorders
5.Patients on anticoagulant therapy.
6.History of allergic reactions attributed to misoprostol or compounds of similar chemical or biologic composition to misoprostol

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood loss at abdominal myomectomy

Secondary Outcome Measures

Name	Time	Method
eed for blood transfusion;Post operative haematocrit;Duration of surgery;Febrile morbidity