Pathophysiology and treatment of nonalcoholic fatty liver disease (NAFLD): Effects of bariatric surgery

Not Applicable

Completed

• Conditions: Obesity; Non-alcoholic fatty liver disease; Bariatric Surgery; Diet and Nutrition - Obesity; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Surgery - Other surgery

• Registration Number: ACTRN12615000874516
• Lead Sponsor: Centre for Obesity Research and Education, Monash University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-08-21
• Study Completion: 2019-08-05
• Last Update Posted: 9 November 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 190

Inclusion Criteria

Patients >17 years undergoing bariatric surgery and any of:
- AST or ALT > 0.5 upper limit normal
- GGT > upper limit normal
- Abnormal transient elastography
- Abnormal ultrasound suggesting NAFLD

Exclusion Criteria

Other cause of liver disease
Past or current excessive ETOH

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in liver histology with surgically induced weight loss (comparison of baseline liver biopsy with follow-up liver biopsy)[1 year]

Secondary Outcome Measures

Name	Time	Method
Changes in immune cell infiltrate and expression of TNFSF14/LIGHT (immune cell related marker) in NASH with weight loss (as investigated via immunohistochemistry of liver). [1 year]