The Effect of Thyroid Antibodies on Female Reproductive Function and Pregnancy Outcomes
- Conditions
- Thyroiditis, Autoimmune
- Interventions
- Registration Number
- NCT04952012
- Lead Sponsor
- Second Affiliated Hospital, School of Medicine, Zhejiang University
- Brief Summary
Some women at reproductive age have positive antithyroid antibodies (ATAs). Thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) are the most common ATAs. This study aimed to evaluate the impact of ATAs on maturation of women reproductive system and pregnancy outcomes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 4000
Inclusion Criteria
- Age during 18-45y;
- Women tested for TPOAb and/or TgAb, TSH, free T3, free T4, total T3 and total T4 during the 1st trimester of pregnancy
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Exclusion Criteria
- Multiple pregnancies;
- Age < 18 y or > 40 y;
- L-T4 or PTU intervention before pregnancy;
- Other autoimmune diseases.
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description ATA-negative LT4 - ATA-positive LT4 -
- Primary Outcome Measures
Name Time Method Incidence rate of pregnancy complications in women with or without thyroid antibodies 1 year
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Second Affiliated Hospital, School of Medicine, Zhejiang University
🇨🇳Hangzhou, Zhejiang, China