ISRCTN13479086
Active, not recruiting
未知
Sex differences in the role of sympathetic nerve activity in the development of hypertension in humans
niversity of Bristol0 sites148 target enrollmentJune 28, 2019
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- niversity of Bristol
- Enrollment
- 148
- Status
- Active, not recruiting
- Last Updated
- 5 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Aged 18\-75 years
- •2\. Hypertensive patients: Office blood pressure \= 140/90 mmHg and daytime ambulatory blood pressure \=135/85 mmHg
- •3\. Normotensive participants: Office blood pressure \< 140/90 mmHg and daytime ambulatory blood pressure \< 135/85 mmHg
- •4\. Postmenopausal women: No period for at least 12 months and not using hormonal contraception (NICE, 2015\)
Exclusion Criteria
- •1\. Secondary causes of hypertension
- •2\. Body mass index \> \= 30 kg/m2
- •3\. Oophorectomy (removal of ovaries) prior to onset of natural menopause
- •4\. Pregnancy/breastfeeding women
- •5\. Taking hormone replacement therapy
- •6\. Taking nitrate, steroid, anti\-coagulant or immunosuppressant medication or medication as part of a clinical trial
- •7\. Major illness e.g. cancer, inflammatory disease (including vasculitis) or receiving palliative care
- •8\. Diagnosed cardiovascular (including arrhythmia), respiratory (including asthma), psychiatric, renal or ophthalmic disease
- •9\. Congenital or acquired neurological conditions (including dementia), language disorders, repeated or chronic pain conditions (excluding menstrual pain and minor sporadic headaches)
- •10\. Diabetes
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Early Phase 1
Sex-related Differences in Sympathetic Vascular Transduction in the Setting of HypoxemiaVasodilationHypoxiaNCT05256069University of Missouri-Columbia31
Completed
Phase 4
The Impact of Biological Gender in Peripheral Nerve Blockade: A Prospective Study in VolunteersGender differences in regional anaesthesiaDRKS00030404Medizinische Universität Wien, Universitätsklinik für Klinische Pharmakologie24
Completed
Not Applicable
Sex Differences in Sympathetic Vascular Reactivity at High AltitudeVasodilationVasoconstrictionNCT05525416University of Alberta17
Completed
Not Applicable
Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia.VasodilationVasoconstrictionNCT05001048University of Alberta14
Recruiting
Not Applicable
Sex differences of brain signals and neuron networks on effort breath by functional magnetic resonance imaging techniques and effort levels of respiratory muscles in artificial effort breathinghealthy subjectsJPRN-UMIN000035310Kurume Univeristy30