NCT05256069已完成早期 1 期
Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia
适应症
干预措施
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 1
- 主要终点
- Forearm Blood Flow
研究概览
简要总结
The purpose of this project is to identify sex-related differences in the effect of hypoxia on sympathetic vascular transduction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy adult men and women;
- •18-45 years of age;
- •BMI 18-30 kg/m2;
- •non-pregnant/non-breastfeeding;
- •non-nicotine users;
排除标准
- •Pregnancy, breastfeeding, hormonal contraceptives
- •Diagnosed sleep apnea
- •Current smoking/Nicotine use/drug use
- •Nerve/neurologic disease
- •Cardiovascular, hepatic, renal, respiratory disease
- •Blood pressure ≥140/90 mmHg
- •Diabetes, Polycystic ovarian syndrome
- •Communication barriers
- •Prescription medications
- •Recent COVID-19 diagnosis with symptoms
研究组 & 干预措施
Hypoxia Exposure
Experimental
Men and women will be exposed to isocapnic hypoxia. Participants will wear a mask and systemic oxygen levels will be titrated to attain hypoxemia as assessed by pulse oximetry.
干预措施: Propranolol Pill (Drug)
Hypoxia Exposure
Experimental
Men and women will be exposed to isocapnic hypoxia. Participants will wear a mask and systemic oxygen levels will be titrated to attain hypoxemia as assessed by pulse oximetry.
干预措施: Placebo (Drug)
结局指标
主要结局
Forearm Blood Flow
时间窗: Change from baseline to 5 minutes
Measured with venous occlusion plethysmography (mL/dL/min)
次要结局
未报告次要终点
研究者
Jacqueline K Limberg, PhD
Assistant Professor
University of Missouri-Columbia
研究点 (1)
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