Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia
Early Phase 1
Recruiting
- Conditions
- HypoxiaVasodilation
- Interventions
- Drug: Placebo
- Registration Number
- NCT05256069
- Lead Sponsor
- University of Missouri-Columbia
- Brief Summary
The purpose of this project is to identify sex-related differences in the effect of hypoxia on sympathetic vascular transduction.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 35
Inclusion Criteria
- healthy adult men and women;
- 18-45 years of age;
- BMI 18-30 kg/m2;
- non-pregnant/non-breastfeeding;
- non-nicotine users;
Exclusion Criteria
- Pregnancy, breastfeeding, hormonal contraceptives
- Diagnosed sleep apnea
- Current smoking/Nicotine use/drug use
- Nerve/neurologic disease
- Cardiovascular, hepatic, renal, respiratory disease
- Blood pressure ≥140/90 mmHg
- Diabetes, Polycystic ovarian syndrome
- Communication barriers
- Prescription medications
- Recent COVID-19 diagnosis with symptoms
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Hypoxia Exposure Propranolol Pill Men and women will be exposed to isocapnic hypoxia. Participants will wear a mask and systemic oxygen levels will be titrated to attain hypoxemia as assessed by pulse oximetry. Hypoxia Exposure Placebo Men and women will be exposed to isocapnic hypoxia. Participants will wear a mask and systemic oxygen levels will be titrated to attain hypoxemia as assessed by pulse oximetry.
- Primary Outcome Measures
Name Time Method Forearm Blood Flow Change from baseline to 5 minutes Measured with venous occlusion plethysmography (mL/dL/min)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Missouri-Columbia
🇺🇸Columbia, Missouri, United States