Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia

University of Missouri-Columbia1 site in 1 country31 target enrollmentApril 26, 2023

ConditionsVasodilation Hypoxia

InterventionsPropranolol Pill Placebo

Overview

Phase: Early Phase 1
Intervention: Propranolol Pill
Conditions: Vasodilation
Sponsor: University of Missouri-Columbia
Enrollment: 31
Locations: 1
Primary Endpoint: Forearm Blood Flow
Status: Completed
Last Updated: 7 months ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this project is to identify sex-related differences in the effect of hypoxia on sympathetic vascular transduction.

Registry

clinicaltrials.gov

Start Date

April 26, 2023

End Date

July 31, 2025

Last Updated

7 months ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

University of Missouri-Columbia

Responsible Party

Principal Investigator

Jacqueline K Limberg, PhD

Assistant Professor

University of Missouri-Columbia

Eligibility Criteria

Inclusion Criteria

•healthy adult men and women;
•18-45 years of age;
•BMI 18-30 kg/m2;
•non-pregnant/non-breastfeeding;
•non-nicotine users;

Exclusion Criteria

•Pregnancy, breastfeeding, hormonal contraceptives
•Diagnosed sleep apnea
•Current smoking/Nicotine use/drug use
•Nerve/neurologic disease
•Cardiovascular, hepatic, renal, respiratory disease
•Blood pressure ≥140/90 mmHg
•Diabetes, Polycystic ovarian syndrome
•Communication barriers
•Prescription medications
•Recent COVID-19 diagnosis with symptoms

Arms & Interventions

Hypoxia Exposure

Men and women will be exposed to isocapnic hypoxia. Participants will wear a mask and systemic oxygen levels will be titrated to attain hypoxemia as assessed by pulse oximetry.

Intervention: Propranolol Pill

Hypoxia Exposure

Men and women will be exposed to isocapnic hypoxia. Participants will wear a mask and systemic oxygen levels will be titrated to attain hypoxemia as assessed by pulse oximetry.

Intervention: Placebo