NCT06261034
Recruiting
Not Applicable
Sex Differences in Neurocirculatory Control With Obstructive Sleep Apnea
ConditionsObstructive Sleep Apnea
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obstructive Sleep Apnea
- Sponsor
- Mayo Clinic
- Enrollment
- 60
- Locations
- 2
- Primary Endpoint
- Blood pressure
- Status
- Recruiting
- Last Updated
- 3 months ago
Overview
Brief Summary
The purpose of this study is to investigate potential sex differences in neurocirculatory control of blood pressure in patients with untreated obstructive sleep apnea (OSA).
Investigators
Joshua M. Bock
Principal Investigator
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- •20-70 years of age
Exclusion Criteria
- •Coronary artery disease
- •Heart failure
- •Pregnancy
- •Sleep disorders other than OSA
- •Shift workers
- •Individuals who typically go to sleep after midnight
- •Individuals who traveled across ≥2 time zones within one week of study visits
- •BMI ≥40.0kg/m2
- •Use of nicotine-containing products within the two years preceding study visits
- •Use of allopurinol, proton pump inhibitors, or other medications/supplements which interfere with outcome measures
Outcomes
Primary Outcomes
Blood pressure
Time Frame: Baseline
Measured in millimeters of mercury (mmHg).
Endothelial function
Time Frame: Baseline
Ultrasound assessment of flow-mediated vasodilation of the brachial artery. Brachial artery diameter and blood velocity will be measured after deflation to measure endothelial function.
Arterial stiffness
Time Frame: Baseline
Measured by applanation tonometry reported as aortic pulse wave velocity (m/sec)
Secondary Outcomes
- Sympathetic nerve burst incidence(Baseline)
- Sympathetic nerve burst amplitude (AU)(Baseline)
- Sympathetic nerve burst frequency(Baseline)
- Total muscle sympathetic nerve activity (MSNA)(Baseline)
Study Sites (2)
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