NCT06261034招募中不适用
Sex Differences in Neurocirculatory Control With Obstructive Sleep Apnea
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- Mayo Clinic
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Blood pressure
研究概览
简要总结
The purpose of this study is to investigate potential sex differences in neurocirculatory control of blood pressure in patients with untreated obstructive sleep apnea (OSA).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •20-70 years of age
排除标准
- •Coronary artery disease
- •Heart failure
- •Pregnancy
- •Sleep disorders other than OSA
- •Shift workers
- •Individuals who typically go to sleep after midnight
- •Individuals who traveled across ≥2 time zones within one week of study visits
- •BMI ≥40.0kg/m2
- •Use of nicotine-containing products within the two years preceding study visits
- •Use of allopurinol, proton pump inhibitors, or other medications/supplements which interfere with outcome measures
结局指标
主要结局
Blood pressure
时间窗: Baseline
Measured in millimeters of mercury (mmHg).
Endothelial function
时间窗: Baseline
Ultrasound assessment of flow-mediated vasodilation of the brachial artery. Brachial artery diameter and blood velocity will be measured after deflation to measure endothelial function.
Arterial stiffness
时间窗: Baseline
Measured by applanation tonometry reported as aortic pulse wave velocity (m/sec)
次要结局
- Sympathetic nerve burst incidence(Baseline)
- Sympathetic nerve burst amplitude (AU)(Baseline)
- Sympathetic nerve burst frequency(Baseline)
- Total muscle sympathetic nerve activity (MSNA)(Baseline)
研究者
Joshua M. Bock
Principal Investigator
Mayo Clinic
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Sex Differences in Risk for Alcohol AbuseAlcohol AbuseNCT04543942Mark Fillmore22
已完成
1 期
Human Cerebral Blood Flow RegulationCerebral Arterial DiseasesNCT04265053University of Wisconsin, Madison42
已完成
不适用
Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia.VasodilationVasoconstrictionNCT05001048University of Alberta14
招募中
不适用
Sex differences of brain signals and neuron networks on effort breath by functional magnetic resonance imaging techniques and effort levels of respiratory muscles in artificial effort breathinghealthy subjectsJPRN-UMIN000035310Kurume Univeristy30
已完成
不适用
Sex Differences in Sympathetic Vascular Reactivity at High AltitudeVasodilationVasoconstrictionNCT05525416University of Alberta17