Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell Disease
- Conditions
- Vaso-occlusive CrisisSickle Cell Disease
- Registration Number
- NCT06345638
- Lead Sponsor
- University of Pennsylvania
- Brief Summary
This study aims to characterize sex differences in the pathophysiology of vaso-occlusive crises (VOC) occurring among individuals with sickle cell disease (SCD).
* The study will compare CRP and other biomarkers between females with SCD in the follicular phase of the menstrual cycle and males with SCD.
* The study will explore potential sex differences in biomarker changes between females and males with SCD during and following resolution of VOC.
* The study will compare neutrophil and platelet adhesion to the endothelium and real time fibrin deposition in the blood.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 52
- Adult males and females aged 18-45
- Diagnosis of sickle cell disease
- current hospitalization for vaso-occlusive pain episode or current outpatient infusion at the recruiting sites
- Able to read and understand English
- Willing to comply with study procedures
- Currently pregnant, pregnant within the last month, or seeking to become pregnant
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method C-reactive protein level 1 month Serum level of hs-CRP
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (3)
Penn Medicine University City
🇺🇸Philadelphia, Pennsylvania, United States
Pennsylvania Hospital
🇺🇸Philadelphia, Pennsylvania, United States
Hospital of the University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States
Penn Medicine University City🇺🇸Philadelphia, Pennsylvania, United States