NCT06345638
Completed
Not Applicable
Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sickle Cell Disease
- Sponsor
- University of Pennsylvania
- Enrollment
- 52
- Locations
- 3
- Primary Endpoint
- C-reactive protein level
- Status
- Completed
- Last Updated
- 9 months ago
Overview
Brief Summary
This study aims to characterize sex differences in the pathophysiology of vaso-occlusive crises (VOC) occurring among individuals with sickle cell disease (SCD).
- The study will compare CRP and other biomarkers between females with SCD in the follicular phase of the menstrual cycle and males with SCD.
- The study will explore potential sex differences in biomarker changes between females and males with SCD during and following resolution of VOC.
- The study will compare neutrophil and platelet adhesion to the endothelium and real time fibrin deposition in the blood.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adult males and females aged 18-45
- •Diagnosis of sickle cell disease
- •current hospitalization for vaso-occlusive pain episode or current outpatient infusion at the recruiting sites
- •Able to read and understand English
- •Willing to comply with study procedures
Exclusion Criteria
- •Currently pregnant, pregnant within the last month, or seeking to become pregnant
Outcomes
Primary Outcomes
C-reactive protein level
Time Frame: 1 month
Serum level of hs-CRP
Study Sites (3)
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