NCT06345638已完成不适用
Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 3
- 主要终点
- C-reactive protein level
研究概览
简要总结
This study aims to characterize sex differences in the pathophysiology of vaso-occlusive crises (VOC) occurring among individuals with sickle cell disease (SCD).
- The study will compare CRP and other biomarkers between females with SCD in the follicular phase of the menstrual cycle and males with SCD.
- The study will explore potential sex differences in biomarker changes between females and males with SCD during and following resolution of VOC.
- The study will compare neutrophil and platelet adhesion to the endothelium and real time fibrin deposition in the blood.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult males and females aged 18-45
- •Diagnosis of sickle cell disease
- •current hospitalization for vaso-occlusive pain episode or current outpatient infusion at the recruiting sites
- •Able to read and understand English
- •Willing to comply with study procedures
排除标准
- •Currently pregnant, pregnant within the last month, or seeking to become pregnant
结局指标
主要结局
C-reactive protein level
时间窗: 1 month
Serum level of hs-CRP
次要结局
未报告次要终点
研究者
研究点 (3)
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