A Comparative evaluation of Dexmedetomidine and Ketamine nebulization in preventing postoperative sore throat following endotracheal intubation
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Incidence and severity of postoperative sore throat
研究概览
简要总结
Post operative sore throat(POST) is a common occurrence following general anesthesia with endotracheal intubation.
Incidence of POST is estimated to be 21%-65% in different studies. Irritation and inflammation of the airway are considered to be the causes of POST.
Although considered as a minor complication, it may cause significant patient morbidity, dissatisfaction, and increased the length of hospital stay.
Nowadays, aerosolised drugs are better accepted and tolerated by the patients than gargle, as it spares them from the bitter taste of the drug.
DEXMEDETOMIDINE is a colorless, tasteless and odorless drug with a selective alpha 2 adrenergic agonistic action, which causes sedation and analgesia.
KETAMINE is an N-methyl-D-aspartate(NMDA) receptor antagonist has anti-nociceptive and anti-inflammatory properties.
To compare the efficacy of preoperative DEXMEDETOMIDINE and KETAMINE nebulization in preventing sore throat following endotracheal intubation
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA I to III patients undergoing general anaesthesia.
排除标准
- •ASA IV Pregnancy.
结局指标
主要结局
Incidence and severity of postoperative sore throat
时间窗: 0, 2, 4, 8, 12 and 24 hours
次要结局
未报告次要终点
研究者
Devashri Vasudevan
SKS Hospital and Post Graduate Medical Institiute