Efficacy of Dexmedetomidine and Dexamethasone gargle on postoperative sore throat: A randomized double blind clinical study.
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- The sore throat and cough will be assessed by interviewing the patients.
研究概览
简要总结
Postoperative sore throat [POST] is a common post operative complication that occurs in14.4% to 73.9% in patient who undergo general anaesthesia with endotracheal intubation. Causes of postoperative sore throat are known to be associated with inflammation and stimulation by endotracheal intubation.
The pharmacological methods that have been found to be effective in decreasing the incidence and severity of post operative sore throat include preoperative gargling with ketamine and magnesium solution, intravenous injection of dexamethasone, gargling and tube soaking with dexamethasone.
Dexmedetomidine, a selective alpha-2 receptor agonist, is also administered for short term sedation in pediatric procedures and in icu, cardiac surgeries to decrease sympathetic tone, bariatric surgeries as it causes less respiratory depression.
Though the effect of dexamethasone nebulization and gargle on post operative sore throat has been studied, the literature on the role of dexmedetomidine gargle is sparse.
We are hypothesizing that preoperative gargle with dexmedetomidine will reduce the incidence and severity of post operative sore throat more effectively than gargle with dexamethasone. Hence this study is designed to compare the effectiveness of preoperative gargle of dexamethasone, dexmedetomidine in reducing the severity of post operative sore throat in patients undergoing endotracheal intubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 20.00 Year(s) 至 45.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients age: 20 to 45 years.
- •Patients of ASA Physical Status classification I and II.
- •Patients requiring endotracheal intubation in laparoscopic cholecystectomy.
排除标准
- •Preoperative sore throat.
- •Patients with history of recent upper respiratory tract infection.
- •Chronic smokers.
- •History of allergy to study drugs.
- •Intubation unsuccessful in first attempt.
- •Pregnant patients.
结局指标
主要结局
The sore throat and cough will be assessed by interviewing the patients.
时间窗: Immediately after extubation. | After 2 hour in post anaersthesia care unit. | After 6 hour in post anaesthesia care unit. | After 12 hour in post anaesthesia care unit. | After 24 hour in post anaesthesia care unit.
次要结局
- To compare the severity of cough in grougs.(To compare the perioperative hemodynamic parameters)
研究者
Mohammad Ehtsham
UTTAR PRADESH UNIVERSITY OF MEDICAL SCIENCES