Study of Hemodynamic Conditions Measured During Hepatectomy

Completed

• Conditions: Liver Dysfunction; Circulatory; Change
• Interventions: Procedure: Liver debit measure

• Registration Number: NCT03371537
• Lead Sponsor: University Hospital, Tours

Brief Summary

Hepatocellular insufficiency is a dreaded complication after hepatectomy, since, if it is persistent, it leads to the death of the patient in the absence of liver transplantation.

The preoperative evaluation aims in particular to estimate the risk of postoperative hepatocellular insufficiency so as to minimize or contraindicate high-risk patients.

It has been shown that the flow of the portal vein is correlated with liver function, especially in the living donor and after portal embolization. More recently, the study of flow rates in the portal vein and the hepatic artery after transplantation has shown a correlation with the recovery of graft function.

The hypothesis is that portal and arterial flow after hepatectomy can predict postoperative hepatocellular function.

Detailed Description

Measurements of flow rates in the portal vein and the hepatic artery by different transit times are available thanks to the Medistim VeriQTM system that the investigators already use routinely in the context of liver transplantation when performing hepatectomies.

Study Timeline

• Study Start: 2017-10-08
• Study First Submitted: 2017-12-08
• Study First Submitted QC: 2017-12-08
• Study First Posted: 2017-12-13
• Primary Completion: 2019-03-19
• Study Completion: 2019-03-19
• Status Verified: 2021-03
• Last Update Submitted: 2021-03-17
• Last Update Posted: 2021-03-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 9

Inclusion Criteria

• patient 18 years or more
• Patient undergoing laparotomy for liver resection

Exclusion Criteria

• Patient under tutorship or curatorship
• Pregnant or lactating woman
• Difficulties in understanding French
• Patient operated by laparoscopy
• Patient having objected to the processing of his data

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Hepatectomy	Liver debit measure	Patient undergoing laparotomy for liver resection. The aim is to measure the flow rates in the portal vein and the hepatic artery.

Primary Outcome Measures

Name	Time	Method
Liver vessel debit	Baseline	Mesure of liver debit during hepatectomy

Trial Locations

Locations (1)

Service de Chirurgie Digestive, Oncologique, Endocrinienne et Transplantation Hépatique, CHRU de TOURS; 🇫🇷 Tours, France