Perioperative Hepatic Blood Flow in relation to Hepatic Regeneration and Function following major Liver Surgery

• Conditions: Liver cancer; liver surgery; 10019815; 10019818

• Registration Number: NL-OMON48919
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Major Hepatectomy defined as
- FLR <30% in normal liver
- FLR <40% in diseased liver including post-chemotherapy

Exclusion Criteria

< 18 years
Intolerance or allergy to paracetamol or 13C-methacetin
Previous splenectomy
Child C cirrhosis
Concomitant RF/Microwave Ablation
Significant Cardiovascular disease
Pregnancy
No written and signed informed consent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Portal Venous Blood flow (Ultrasound)<br /><br>Hepatic Artery Blood flow (Ultrasound)<br /><br>Hepatic Artery Resistance Index (Ultrasound)<br /><br>ICG retention after 15 minutes (ICG-R15)<br /><br>ICG plasma disappearance rate (ICG-PDR)<br /><br>Maximum Liver Function Capacity by (LiMAx)<br /><br>Liver remnant volume by (CT Volumetry) </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Routine laboratory Liver function parameters<br /><br>Routine Hemodynamic parameters<br /><br>Clinical Outcomes: length of stay, Ventilator time, ICU readmission, Death</p><br>