Work of Breathing and Oxygen Saturation in Infants Receiving High Flow Nasal Cannula (HFNC)

Completed

• Conditions: High Flow Nasal Cannula
• Interventions: Other: Enrollment

• Registration Number: NCT03529994
• Lead Sponsor: Christiana Care Health Services

Brief Summary

The purpose of this study is to compare work of breathing on different levels of high flow respiratory support on infants born between 27 and 37 weeks gestation.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-04-15
• Study First Submitted: 2018-05-08
• Study First Submitted QC: 2018-05-08
• Study First Posted: 2018-05-21
• Status Verified: 2019-05
• Primary Completion: 2019-07-31
• Study Completion: 2019-08-01
• Last Update Submitted: 2019-08-27
• Last Update Posted: 2019-08-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Infants between 27 and 37 weeks corrected gestational age
• >4 days PNA
• Stable (i.e. not meeting exclusion criteria) and receiving non-invasive respiratory support (HFNC) for ≥ 12 hours
• Requiring ≤ 40% supplemental FiO2 as determined by the clinical care team for clinical care purposes independent of this study

Exclusion Criteria

• Infants with skeletal, neuromuscular, or abdominal surgical disorders that affect the accuracy of WOB measurements

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Enrollment	Enrollment	-

Primary Outcome Measures

Name	Time	Method
Work of breathing indices	2 hours	Altering HFNC flow rates and its effect on work of breathing indices in preterm infants with respiratory insufficiency.

Secondary Outcome Measures

Name	Time	Method
Intermittent hypoxia	2 hours	Altering HFNC flow rates and its effect on intermittent hypoxia in preterm infants with respiratory insufficiency.

Trial Locations

Locations (1)

Christiana Care Health Services, Inc.; 🇺🇸 Newark, Delaware, United States