Effects of O2 and/or CO2 Inhalation on Rest and Exercise Pulmonary Hemodynamic

Completed

• Conditions: Hypercapnia; Pulmonary Vascular Sensibility in Hypoxia; Hypoxia and Hypercapnia
• Interventions: Device: Hypoxia and hypercapnia (Altitrainer NP 190); Device: Hypercapnia inhalation (Altitrainer NP 190); Device: Hypoxia inhalation (Altitrainer NP 190)

• Registration Number: NCT01898858
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

The aim of this study is to describe the pulmonary hemodynamic evolution at rest and during a short constant load exercise in 4 conditions :

* normoxia

* hypoxia

* hypercapnia

* association hypoxia and hypercapnia

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-06-21
• Study First Submitted QC: 2013-07-11
• Study First Posted: 2013-07-12
• Study Start: 2013-09
• Status Verified: 2014-10
• Primary Completion: 2014-10
• Study Completion: 2014-10
• Last Update Submitted: 2014-10-14
• Last Update Posted: 2014-10-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 8

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
HYPOXIA + HYPERCAPNIA	Hypoxia and hypercapnia (Altitrainer NP 190)	-
HYPERCAPNIA	Hypercapnia inhalation (Altitrainer NP 190)	-
HYPOXIA	Hypoxia inhalation (Altitrainer NP 190)	-

Primary Outcome Measures

Name	Time	Method
Systolic Artery Pulmonary Pressure(sPAP) (echocardiography, Cardiac output (impedancemetry), Cardiorespiratory parameters	at the end of the 30th minutes constant load exercise	At rest and during exercise for each condition

Secondary Outcome Measures

Name	Time	Method
Dyspnea and muscle leg discomfort using a Borg Scale	at the end of the 30th minutes constant load exercise	In each conditions at rest and during exercise

Trial Locations

Locations (1)

Service de Physiologie et d'Explorations Fonctionnelles, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg; 🇫🇷 Strasbourg, France