Determination of Adipocytokine in Synovial Fluid of Osteoarthritis Patients With Joint Pain and Effusion
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- Determination of adipocytokine levels (adiponectin, leptin, resistin, visfatin, osteopontin) in synovial fluid
研究概览
简要总结
The purpose of this study is to determine the concentration of different adipocytokine (adiponectin, leptin, resistin, visfatin, osteopontin) and an inflammation classic markers as Interleukine 1 beta, tumor necrosis alfa, interleukine 6 and high sensibility reactive c protein in the synovial fluid of knee osteoarthritis patients, and compare with the inflammation detected with ultrasonography evaluation of the joint. In last years, some studies appeared focusing on the role of adipocytokines in osteoarthritis and they correlated adipocytokines with cartilage degradation and x-ray degree; in our study we will focused in the importance of adipocytokines in the inflammatory changes more than in joint destruction.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 50 Years 至 81 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged 50 to 81
- •primary osteoarthritis of the knee
- •synovial effusion in examination
- •patient who have the results in our database
排除标准
- •any other rheumatic conditions as rheumatoid arthritis or another inflammatory disease
- •secondary knee osteoarthritis
- •history of knee surgery
- •any conditions that at investigator criteria exclude the patient from study procedures
结局指标
主要结局
Determination of adipocytokine levels (adiponectin, leptin, resistin, visfatin, osteopontin) in synovial fluid
时间窗: We determine adipocytoquines in one month, all patients in the same determination kit
We have all the synovial fluid freeze, so now we have to determine the levels of everyone.
次要结局
- Knee inflammation parameters detected by ultrasonography(three months)
- To determine additional classic parameters of inflammation in synovial fluid as Interleukine 1 beta, Interleukine 6 and tumor necrosis factor alfa(We determine this inflammatory parameters in one month in all patient at the same time)
研究者
Joan Calvet Fontova
Dr
Parc Taulí Hospital Universitari