Influence of Adipocytokines in Osteoarthritis

• Conditions: Cardiovascular Risk Factors; Osteoarthritis, Knee; Endocrine System Diseases
• Interventions: Other: Blood analyse, arthrocentesis, ultrasound examination

• Registration Number: NCT01906281
• Lead Sponsor: Parc Taulí Hospital Universitari

Brief Summary

Adipocytokines play an important role in joint inflammation in patients with knee osteoarthritis as measured by ultrasound and high sensitivity protein-C reactive. Adipocytokines could be the link between osteoarthritis and cardiovascular risk factors more prevalent in these patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-07
• Study First Submitted: 2013-07-05
• Study First Submitted QC: 2013-07-19
• Study First Posted: 2013-07-24
• Status Verified: 2013-11
• Last Update Submitted: 2013-11-07
• Last Update Posted: 2013-11-08
• Primary Completion: 2014-11
• Study Completion: 2014-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 105

Inclusion Criteria

• Patients over 50 years old with symptomatic knee osteoarthritis.

Exclusion Criteria

• Patients with secondary osteoarthritis of the knee
• Any other rheumatologic condition.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Non-inflammatory knee osteoarthritis	Blood analyse, arthrocentesis, ultrasound examination	Patients with no inflammatory condition in physical examination. We will make a blood analyse and arthrocentesis when synovial fluid were found in ultrasound examination. Ultrasound of affected knee and carotid artery will be performed.
Inflammatory knee osteoarthritis	Blood analyse, arthrocentesis, ultrasound examination	One group of patients with inflammatory condition in physical evaluation. We will make a blood analyse and arthrocentesis when synovial fluid were found in ultrasound examination. Ultrasound of affected knee and carotid artery will be performed.

Primary Outcome Measures

Name	Time	Method
adipocytokine level	18 months	We will determine the adipocytokine level at the end of inclusion period between 12-18 months

Secondary Outcome Measures

Name	Time	Method
Ultrasound inflammatory exploration of the knee	18 months	we evaluate the presence of synovial fluid with ultrasound evaluation in the visit of the patient. Ultrasound evaluation will be performed by two Rheumatologists.
Ultrasound of carotid artery	18 months	We will evaluate patients with ultrasound exploration in order to describe the presence of atheromatous disease in the visit of the patient
Cardiovascular risk factors	18months	We evaluate the prevalence of cardiovascular risk factors in the symptomatic knee osteoarthritis patients, and the relationship with adipocytokines. We will evaluate blood analyse levels of cholesterol, glycemia.

Trial Locations

Locations (2)

Hospital Parc Tauli Sabadell; 🇪🇸 Sabadell, Barcelona, Spain

Hospital Parc Tauli; 🇪🇸 Sabadell, Barcelona, Spain