General anesthesia versus sedation with high-flow nasal cannula for the endovascular treatment of acute ischemic stroke
- Conditions
- Acute ischemic strokeTherapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
- Registration Number
- CTIS2024-510752-12-00
- Lead Sponsor
- Hospital Universitario La Paz
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 116
Age greater than or equal to 18 years., NIHSS = 6 and = 25., Anterior circulation stroke with isolated or combined occlusion of: - Intracranial Internal Carotid Artery. - Middle Cerebral Artery in its M1 or M2 segments., Time of evolution from clinical onset to radiology ward admission < 6 hours, or < 24 hours since last seen asymptomatic if salvageable tissue is demonstrated on neuroimaging tests., Informed consent signed by the patient if capable, or by a family member/legal representative if the patient is not capable.
Coma on admission (Glasgow Coma Scale < 8)., Baseline severe dependency status (mRS>3)., Severe/significant agitation on admission., Objective loss of airway protection reflexes or vomiting on admission., Failure to comply with fasting (6 hours of solids and 2 hours of clear liquids)., Known or suspected difficult airway on examination., Allergy or intolerance to any of the medications used for sedation or general anesthesia., Recent maxillofacial trauma/surgery., Acute cerebral hemorrhage or clear hemorrhagic transformation in the same vascular territory., Thrombopenia <50,000 or severe coagulation disturbances.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method