The reservecapacity of the peritoneum with the NO donor sodium nitroprusside during peritoneal dialysis

Conditions: aandoeningen ten gevolge van behandeling met peritoneale dialyse als nierfunctie vervangende therapie
peritoneal membrane failure = impairment to remain on a certain dry weight with peritoneal dialysis

Registration Number: NL-OMON30602

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

Patients > 18 years of age treated with peritoneal dialysis > 1 month and < 1 year
Patients > 18 years of age treated with peritoneal dialysis > 3 years

Exclusion Criteria

Patients with peritonitis less than 4 weeks prior the investigation
Severe overhydration
Signs of hypersensitivity for dextrans
Systolic bloodpressure < 120 mmHg en/of diastolic bloodpressure < 80 mmHg
No informed consent

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the difference in transport of small solutes by<br /><br>means of the mass transfer area coefficient (MTAC) of creatinine between the<br /><br>SPA with and without the addition of the vasodilator sodium nitroprusside. The<br /><br>difference in MTAC-creatinine between these SPAs will be compared between the<br /><br>short-term and the long-term PD group.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters will be differences between the SPA with and without<br /><br>sodium nitroprusside in:<br /><br>- Peritoneal solute transport of other small solutes: MTACs of the small<br /><br>solutes urea, urate and dialysate over plasma ratios (D/P) of creatinine, urea,<br /><br>urate, peritoneal glucose absorption<br /><br>- Intrinsic permeability for macromolecules: clearances of 2-Microglobulin,<br /><br>albumin, immunoglobulin-G, 2-macroglobulin<br /><br>- Peritoneal fluid kinetics<br /><br>- Pore sizes of the peritoneal membrane<br /><br><br /><br>The baseline characteristics (age, gender, PD duration, end stage renal<br /><br>disease), markers for the peritoneal membrane, peritoneal membrane thickness of<br /><br>the patients will be described and analyzed for differences between the 2<br /><br>groups. </p><br>