Leucine Supplementation in Elderly Men
Phase 1
Completed
- Conditions
- SarcopeniaAtrophyAging
- Registration Number
- NCT00807508
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
In the present study the investigators aim to determine whether leucine supplementation can augment muscle mass and strength and improve body composition in healthy elderly men
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 29
Inclusion Criteria
- living independently
Exclusion Criteria
- Diabetes cardiovascular disease orthopedic limitations history of resistance training in past 5 years
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method muscle mass and body composition before and after 12 wk intervention
- Secondary Outcome Measures
Name Time Method muscle strength before and after 12 wk intervention
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular pathways does leucine supplementation modulate in sarcopenia of aging, particularly mTOR and muscle protein synthesis?
How does leucine supplementation compare to resistance training or other BCAA interventions in improving muscle mass and strength in elderly men with sarcopenia?
Which biomarkers, such as serum leucine levels or mTOR activity, predict response to leucine supplementation in sarcopenia management?
What are the safety profiles and adverse event management strategies for leucine supplementation in Phase 1 trials targeting elderly sarcopenia?
Are there synergistic effects when combining leucine with HMB or anabolic agents in combating age-related muscle atrophy?
Trial Locations
- Locations (1)
Maastricht University Medical Centre
🇳🇱Maastricht, Netherlands
Maastricht University Medical Centre🇳🇱Maastricht, Netherlands