Bone density as outcome parameter in haemophilia treatment

Completed

• Conditions: 10005330; 10005959; brittle bones disease; osteoporosis; 10064477

• Registration Number: NL-OMON36273
• Lead Sponsor: Malmö University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

Severe haemophilia (FVIII/IX < 1%), adult (minimum age 18 yrs), born from 1970 onwards
signed informed consent
treated according to Van Creveldklniniek protocol (prophylaxis)
participatie in studie (High dose vs intermediate dose prophylaxis for severe haemophilia: long term outcome and costs. METC UMCU nummer 06-002).

Exclusion Criteria

inhibitors against FVIII/IX
malignant bone metastasis present
currently treated with corticosteroids
weight > 135 kilogram

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Bone densitometry results total BMD, expressed as Z score</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Physical activity measured by the MAQ questionnaire (short version, self<br /><br>adiministered- (already collected for Dutch patients)<br /><br>Joint status using the Hhaemophilia Joint Health<br /><br>Score-(already collected for Dutch patients)</p><br>