Cartography of Social Cognition Network and Their Alterations in Patients with Epilepsy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 4
- 主要终点
- angular dispersion (degree/m) of axons in long and short white matter tracts involved in social cognition, in healthy subjects and patients with epilepsy
研究概览
简要总结
Social cognition, which refers to the ability to interpret social information and behave accordingly in a social environment, is crucial in everyday life. But this ability has been shown to be altered in patients with epilepsy, especially in medial temporal lobe epilepsy, which leads to a deterioration in the patient's quality of life. However, the mechanisms of those deficiencies remain largely unknown. The Team objective is to achieve a structural and functional cartography of the social cognition network in 20 healthy subjects and 20 patients with drug-resistant medial temporal lobe epilepsy (before and one year after resective surgery of the epileptogenic focus). Social cognition deficiencies will be assessed using a specifically dedicated neuropsychological assessment validated in French (Batteries de Cognition Sociale BCS). Brain structural analyses will be performed on a 3-Tesla MRI (3T MRI), including an anatomical T1 sequence, a High Angular Resolution Diffusion Imaging (HARDI) to assess the morphology and macrostructural characteristics of long and short white matter tracts involved in social cognition, and quantitative MRI and Hybrid Diffusion Imaging (HYDI) to assess their microstructure. Functional connectivity will be assessed using an ultra-high-field 7-Tesla MRI (7T MRI), with acquisition in resting state and during specific social cognition tasks. Joint analysis of structural and functional connectivity will enable the team to assess the alterations of social cognition networks in patients with epilepsy and their reorganisations after epilepsy surgery.
详细描述
Social cognition refers to the ability to understand others behaviours and emotions, and to adapt its own behaviour given the social context. It is a high-order cognitive function, which requires several processes: identifying some information as carrying a social meaning (such as emotions or facial expressions), decoding this information, inferring the emotional state of one's interlocutor from that information, and using that information and those inferences to adapt its own behaviour.
Social cognition deficiencies are found in many neurological (lobar frontotemporal dementia, epilepsy...) or psychiatric (schizophrenia, autistic spectrum disorders...) diseases and lead to substantial deterioration in the quality of life of the patients, and hamper their integration into society. However, brain alterations and pathophysiological mechanisms leading to those deficiencies are still poorly known.
Brain areas subserving the social cognition have been studied over the past few years, but a global view of this network is lacking. Indeed, most studies focused on a particular aspect of social cognition, such as, for example, facial emotion recognition. The main cortical areas and white matter tracts involved in the successive stages of the social cognition are resumed thereafter.
- Neurological basis of social stimuli perception Social stimuli in everyday life mainly are in visual modality, and secondly in auditory modality. The majority of existing studies thus focused on visual social stimuli.
The very first step of a visual social stimuli processing is its identification, and various cortical areas are devoted to the recognition of a stimuli specifically emitted by another human being. Some areas demonstrated a high specificity for human face recognition : the Occipital Face Area (OFA) in the inferior occipital gyrus, and the Fusiform Face Area (FFA) in the fusiform gyrus. Similarly, some areas are devoted to the recognition of human bodies : the Extrastriate Body area in the lateral occipito-temporal cortex, and the Fusiform Body Area in the fusiform gyrus.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
angular dispersion (degree/m) of axons in long and short white matter tracts involved in social cognition, in healthy subjects and patients with epilepsy
时间窗: 12 months
angular dispersion (degree/m) of axons
Measure of fractional anisotropy (scalar parameters, between 0 and 1) of long and short white-matter tracts involved in social cognition, in healthy subjects and patients with epilepsy
时间窗: 12 months
fractional anisotropy (scalar parameters, between 0 and 1)
measure of mean diffusivity (in mm2/s) of long and short white matter tracts involved in social cognition, in healthy subjects and patients with epilepsy
时间窗: 12 months
mean diffusivity (in mm2/s)
number of fibers in each long and white matter tracts involved in social cognition
时间窗: 12 months
number of fibers in each long and white matter tracts involved in social
measure of functional MRI (fMRI) cortical activations in social cognition networks (measure : % of BOLD signal change), in healthy subjects and patients with epilepsy
时间窗: 12 months
(measure : % of blood-oxygen-level-dependent (BOLD) signal change)
次要结局
- Measure of fractional anisotropy (scalar parameters, between 0 and 1) of long and short white-matter tracts involved in social cognition in patients with epilepsy 1year after surgery(24 months)
- Angular dispersion (degree/m) of axons in long and short white matter tracts involved in social cognition, in patients with epilepsy 1 year after surgery(24 months)
- Measure of fMRI cortical activations in social cognition networks (measure : % of BOLD signal change), in patients with epilepsy 1 year after surgery(24 months)
- Measure of mean diffusivity (in mm2/s) of long and short white matter tracts involved in social cognition, in patients with epilepsy 1 year after surgery(24 months)
- Number of fibers in each long and white matter tracts involved in social cognition(24 months)