NCT00343070已完成2 期
Functional Neuroimaging in Depression: Longitudinal Study of PET Metabolism in Correlation With Changes in Attentional Bias, Autobiographical Memory, Future Fluency and Facial Recognition in Depressed Patients Treated With Escitalopram.
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 4
- 主要终点
- Brain metabolism
研究概览
简要总结
Oral administration of escitalopram during 8 weeks; PET scan with 18F-FDG at inclusion and after 8 weeks
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Major Depression, Depressive episode, following DSM-IV criteria
- •MADRS-score > 25
- •Age: 18-65 yrs
- •Medication-free or anti-depressant wash-out 7 days (for fluoxetine: 6 weeks)
- •Lorazepam 1mg or zolpidem 10mg are allowed
排除标准
- •Suicidality
- •Bipolar disorder, following DSM-IV criteria
- •Psychotic symptoms
- •Substance abuse
- •Personality disorder, following DSM-IV criteria
- •Cognitive dysfunction due to trauma capitis or dementia
- •Diabetes mellitus
- •Women without contraceptive protection, with pregnancy or breast feeding
- •Pharmacological treatment or ingestion of substance that can influence cerebral perfusion less than a month before inclusion
- •IQ below 80
- •Conditions not compatible with SPC
结局指标
主要结局
Brain metabolism
次要结局
- Cognitive functions
- Efficacy scales (mood, anxiety, anger and hopelessness)
研究者
研究点 (4)
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