Comparison Efficacy of Nebulized Magnesium Sulphate to Intravenous Magnesium Sulphate in Children With Severe Acute Asthma
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Asthma severity score
研究概览
简要总结
The purpose of this study is to determine whether nebulized magnesium sulphate is effective in the treatment of acute severe asthma when comparison with intravenous magnesium sulphate
详细描述
Intervention: At randomization eligible patients were allocated to receive 2.5ml of isotonic magnesium sulphate (150 mg,245 mmol/L) on three occasional at 20 minutes interval or standard treatment 50 mg/kg intravenous magnesium sulphate. The asthma severity score was record at 0,20,40,60,120,180,240 minutes post randomization. Adverse event were assessed at each assessment point. Patients were followed up until discharge from hospital to collect secondary outcome data.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 2 Years 至 15 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children age 2-15 years presenting with severe asthma or persistent wheeze without responding to conventional therapy
排除标准
- •chronic lung disease
- •history of adverse reaction form magnesium sulphate
- •life threatening condition
研究组 & 干预措施
isotonic magnesium sulphate
2.5 ml of isotonic magnesium sulphate (150 mg, 245 mmol/L) on three occasional at 20 minutes interval
干预措施: isotonic magnesium sulphate (Drug)
50% magnesium sulphate
magnesium sulphate 50mg/kg/dose intravenous drip in 20 minutes for one dose
干预措施: 50% magnesium sulphate (Drug)
结局指标
主要结局
Asthma severity score
时间窗: 60 minute
次要结局
- Length of stay in the hospital(within 2 weeks)
研究者
Tassalapa Daengsuwan
medical doctor
Queen Sirikit National Institute of Child Health