Comparasion of Efficacy of Nebulized Magnesium Sulphate With Intravenous Magnesium Sulphate in Children With Acute Asthma
Overview
- Phase
- Phase 4
- Intervention
- Nebulized Magnesium sulfate
- Conditions
- Asthma in Children
- Sponsor
- Saima Khatoon
- Enrollment
- 148
- Locations
- 1
- Primary Endpoint
- Efficacy of nebulized magnesium sulphate with intravenous magnesium sulphate in children with acute asthma will be assessed by a drop in PAS score, as assessed at 6 hours of intervention.
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The purpose of study is to assess the effectiveness of nebulized magnesium sulphate in children presenting with acute asthma.Study perfoma consists of demographic variables,exclusion criteria and pediatric asthma score that includes respiratory rate,SPO2 at room air(requirement of oxygen),auscultatory findings in chest,dysnea and retractions.
Detailed Description
After getting informed consent from guardian,148 patients of acute moderate ro severe asthma with pediatric asthma score 8-15 will be randomly classified into 2 groups and one group will receive nebulization with magnesium sulphate and other will receive intravenous magnesium sulphate and effectiveness will be compared by 4 point reduction in PAS from baseline in either groups after 6 hours.
Investigators
Saima Khatoon
Post Graduate Resident in Pediatrics (MD Paeds)
King Edward Medical University
Eligibility Criteria
Inclusion Criteria
- •patients with age 2 to 12 years with acute moderate to severe exacerbation of asthma as per operational definition children who are unrespoinsive to standard treatment of asthma at 60 minutes
Exclusion Criteria
- •those with history of chronic lung disease and abnormal renal function contraindication for MgSO4 due to hepatic or renal disease allergy to MgSo4 children who has other comorbid illness
Arms & Interventions
Nebulized magnesium sulphate
100mg of mgso4 in 20ml of normal saline via ultrasonic nebulizer
Intervention: Nebulized Magnesium sulfate
Intravenous magnesium sulphate
Magnesium sulphate according to weight will be given intravenously.
Intervention: Intravenous magnesium sulphate
Outcomes
Primary Outcomes
Efficacy of nebulized magnesium sulphate with intravenous magnesium sulphate in children with acute asthma will be assessed by a drop in PAS score, as assessed at 6 hours of intervention.
Time Frame: 6 hours
The intervention will be considered effective if there is a drop of at least 4 points in PAS score at hour-6 of intervention.
Secondary Outcomes
- duration of hospital stay(120 hours/5 days)
- duration of ICU stay(72 hours/3 days)