The protective versus conventional ventilation during laparoscopic surgery trial

Not Applicable

• Conditions: Post-operative pulmonary complications; Major laparoscopic surgery; Anaesthesiology - Other anaesthesiology; Surgery - Other surgery

• Registration Number: ACTRN12622001235796
• Lead Sponsor: Austin Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-09-13
• Last Update Posted: 19 September 2022

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 1750

Inclusion Criteria

Equal to or greater than 40 years
Scheduled to have major laparoscopic surgery (including robotic surgery) with an expected duration of more than two hours
Expected to have invasive arterial pressure monitoring as part of their routine care

Exclusion Criteria

Pregnancy
Scheduled to have cardiac, thoracic, or intracranial neurological surgery
Need of nitrous oxide administration
Previously had lung surgery
Planned reintubation after surgery (e.g., planned re-operations)
Received invasive ventilation for longer than 12 hours within the last 30 days prior to surgery
Any other contra-indication to hypercapnia
Previous randomization into this clinical trial

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute respiratory failure (defined as a postoperative PaO2 < 60 mmHg on room air, a PaO2 to FiO2 ratio of less than 300 mmHg or arterial oxyhaemoglobin saturation measured with pulse oximetry less than 90% and requiring oxygen therapy during the first 7 in-hospital post-operative days.[A review of hospital records will be performed to determine the onset of acute respiratory failure as documented in the patient's electronic medical record for a period of 7 days after the laparoscopic surgery was performed.]