The Effects of Different Anesthetics on Functional Connectivity in Volunteers and Patients With Brain Tumor (ACTION)
Overview
- Phase
- Not Applicable
- Intervention
- Dexmedetomidine
- Conditions
- Sedation
- Sponsor
- Beijing Tiantan Hospital
- Enrollment
- 240
- Locations
- 1
- Primary Endpoint
- Amplitude of Low Frequency Fluctuations（ALLF）and Regional Homogeneity（ReHo)
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
This research is a prospective cohort study. The aim of the study is to determine different levels of sedative mechanism and the effect on brain functional connectivity of midazolam, dexmedetomidine and propofol.
Detailed Description
This research will include 120 healthy volunteers and 120 brain tumor patients; the participants will be allocated into midazolam, dexmedetomidine and propofol group. Resting and task fMRI will be performed at awake (BIS\>90), mild sedation (BIS 80-85), moderate sedation (BIS 65-75), deep sedation (BIS 45-55) and recovery states (BIS \>90). The primary outcome of our study is the effect of different levels of sedation for brain network connection. The secondary outcomes are the effect of different levels of sedation for default, executive control, sensory and motor networks and their subnetwork connectivity; the sedation state, circulatory and respiratory parameters of the participants, and the adverse events.
Investigators
Ruquan Han
professor
Beijing Tiantan Hospital
Eligibility Criteria
Inclusion Criteria
- •Male, 18 \~ 65 years old
- •Healthy Volunteer / Brain Tumor Patients
- •Senior high school and above
- •Sign informed consent
Exclusion Criteria
- •In vivo implant MRI check taboo
- •Cardiopulmonary liver and kidney and other systemic complications
- •History of major surgical anesthesia
- •Abuse of drugs, alcoholism history
- •Test drug allergy history
- •Claustrophobia
Arms & Interventions
dexmedetomidine
dexmedetomidine sensation group
Intervention: Dexmedetomidine
Midarolam
midarolam sensation group
Intervention: Midazolam
Propofol
propofol sensation group
Intervention: Propofol
Outcomes
Primary Outcomes
Amplitude of Low Frequency Fluctuations（ALLF）and Regional Homogeneity（ReHo)
Time Frame: 30mins after administration
The differences of amplitude of low frequency fluctuations (ALFF/Low Frequency Amplitude) and regional homogeneity（ReHo) in brain voxel - wise under anesthetic sedations.