Accuracy of CNAP PPV Under General Anaesthesia

Completed

• Conditions: General Anaesthesia

• Registration Number: NCT02166580
• Lead Sponsor: University Hospital Schleswig-Holstein

Brief Summary

Noninvasive pulse pressure variation for the guidance of perioperative fluid therapy is compared with the gold standard of invasive measurements. Cardiac output is derived by the PICCO monitor.

Hypothesis: Noninvasive CNAP PPV predicts fluid responsiveness. A grey zone for the prediction of fluid responsiveness will be defined.

Detailed Description

Accuracy of PPV measured by two devices,PICCO and CNAP, is compared with the manually calculated PPV from the arterial line waveform. Established tests like passive leg raising and end-expiratory occlusion are used for prediction of fluid responsiveness. Intraoperative events like volume challenge are monitored.

Study Timeline

• Study First Submitted: 2012-12-04
• Study Start: 2014-01
• Study First Submitted QC: 2014-06-15
• Study First Posted: 2014-06-18
• Primary Completion: 2015-07
• Study Completion: 2015-07
• Status Verified: 2017-06
• Last Update Submitted: 2017-06-03
• Last Update Posted: 2017-06-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

• major surgery
• need for invasive arterial measurements

Exclusion Criteria

• age under 18
• cardiac dysrhythmia
• vascular pathology at punction site

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cardiac output	1, 2, 5, 10, 15 and 20 minutes after volume challange and	Improvement of cardiac output dependent on PPV before volume challenge

Trial Locations

Locations (1)

University Hospital, Schleswig-Holstein. Departement of Anaesthesiology and Intensive Care Medicine; 🇩🇪 Kiel, Germany