Recurrence Monitoring in NSCLC Using Circulating Tumor DNA
- Conditions
- Non Small Cell Lung Cancer
- Registration Number
- NCT03878537
- Lead Sponsor
- Scripps Translational Science Institute
- Brief Summary
This research study is investigating the role of cell free tumor DNA profiling in determining disease relapse and/or progression for patients with advanced NSCLC.
- Detailed Description
The objective of this study is to determine the ability of cell free tumor DNA genomic profiling to predict disease relapse or progression while on therapy for advanced stage NSCLC in comparison to current standard objective measures of disease relapse or progression.
This study is a prospective observational study. The investigators will assess whole genome sequencing from patient blood samples collected alongside routine blood draws with each treatment cycle to determine the tumor load score at each timepoint while on therapy. CT images will be obtained at routinely ordered timepoints throughout therapy and will be used in the assessment for standard clinical or radiographic evidence of disease progression. These methods of measuring disease progression will be compared in a lead time analysis.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
- Treatment naïve biopsy confirmed not surgically resectable stage III or greater NSCLC
- Baseline CT imaging available
- Patients unable to undergo biopsy for initial tissue diagnosis
- Patients who do not wish to pursue standard of care therapy
- Patients with another diagnosis of malignancy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Progression Free Survival 24 months Clinical or radiographic based PFS
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Scripps Health/Scripps Clinic Hillcrest/Scripps Clinic Torrey Pines
🇺🇸San Diego, California, United States