Effects of Exercise Intervention on Muscle Strength in Severely Ill Patients

Not Applicable

Completed

• Conditions: Intensive Care Unit Patients
• Interventions: Other: exercise bike

• Registration Number: NCT05342129
• Lead Sponsor: Taipei Veterans General Hospital, Taiwan

Brief Summary

In recent years, due to the improvement in the survival rate of the intensive care unit, the problem of severe systemic fatigue (Intensive care unit acquired weakness; ICUAW) has continued to receive attention. Muscle mass decreases by 3-11% within a week, resulting in decreased muscle strength and muscle atrophy. Current studies suggest that ICUAW can lead to poorer function, prolonged ICU stay, and decreased quality of life.

This study aimed to understand the muscle strength of critically ill patients and to explore the effect of exercise intervention on improving muscle strength. The experimental group received a four-week exercise bike intervention plus conventional rehabilitation exercises, while the control group received conventional rehabilitation exercises.

Detailed Description

The content of the exercise is to use an exercise bike, start pedaling on the first day, time setting: 20 minutes, speed: 2, and adopt passive mode. If you can complete the exercise on the first day, the time will be adjusted to 30 minutes on the second day. If you cannot complete the exercise on the first day, the time will still start from 20 minutes on the second day. The maximum time is 30 minutes. If you can complete 30 minutes of passive exercise for 3 consecutive days, the fourth day will be adjusted to active exercise. The entire exercise training is seven days a week, once a day, once a 30-minute, at least 5 days. Those who were discharged to the general ward continued to complete this exercise training for up to 28 days. Stop exercising if heartbeat \> 140, mean arterial pressure \< 65, blood oxygen \< 90%, respiration \> 35 beats/min, or the patient requests to stop during exercise.

Study Timeline

• Study Start: 2020-07-17
• Primary Completion: 2022-03-01
• Study Completion: 2022-03-01
• Study First Submitted: 2022-03-02
• Status Verified: 2022-04
• Study First Submitted QC: 2022-04-18
• Last Update Submitted: 2022-04-18
• Study First Posted: 2022-04-22
• Last Update Posted: 2022-04-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Aged over 20 years old
2. Conscious
3. willing to participate in this study, and signed the consent form
4. no lower extremity activity taboo, and can walk independently before admission

Exclusion Criteria

1. Have neuromuscular disease.
2. Unable to step on a bed bike.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
exercise bike	exercise bike	exercise is to use an exercise bike, start pedaling on the first day, time setting: 20 minutes, speed: 2, and adopt passive mode. If you can complete the exercise on the first day, the time will be adjusted to 30 minutes on the second day. If you cannot complete the exercise on the first day, the time will still start from 20 minutes on the second day. The maximum time is 30 minutes. If you can complete 30 minutes of passive exercise for 3 consecutive days, the fourth day will be adjusted to active exercise. The entire exercise training is seven days a week, once a day, once a 30-minute, at least 5 days. Those who were discharged to the general ward continued to complete this exercise training for up to 28 days.

Primary Outcome Measures

Name	Time	Method
body mass index	baseline	Health Assessment Form
The daily observation record sheet includes	up to 28 days	Vital signs,respirator is used or not,bicycle use pattern,speed and time,reasons for stopping
days on ventilator	baseline	Health Assessment Form
total days in hospital	baseline	Health Assessment Form
Basic Demographic Health Assessment Form	baseline	Age, sex, diagnosis, disease severity, reason for ICU admission
level of albumin	baseline	Health Assessment Form
days in intensive care unit	baseline	Health Assessment Form

Secondary Outcome Measures

Name	Time	Method
Hand grip strength	28 days after intervention(T7)	Using a Grip Strength Tester to Measure Dominant Hand Muscle Strength
walking distance in 6 minutes	28ays after intervention(T7)	Measure 6-minute walking distance
foot lift	28days after intervention(T7)	Use a tape to measure foot lift

Trial Locations

Locations (1)

TaipeiVGH; 🇨🇳 Taipei, Taipei City, Taiwan, Taiwan