Effect of Left Atrial Appendage Velocity on Left Atrial Structure and Function After Radiofrequency Ablation Combined With Left Atrial Appendage Occlusion

Completed

• Conditions: Left Atrial Function; Left Atrial Structure; Left Atrial Appendage Velocity
• Interventions: Device: Transesophageal ultrasound

• Registration Number: NCT04693871
• Lead Sponsor: The Second Hospital of Hebei Medical University

Brief Summary

Radiofrequency ablation of atrial fibrillation combined with left atrial appendage closure can not only improve symptoms in patients with non-valvular atrial fibrillation, but also prevent left atrial appendage thrombosis. The safety and effectiveness of left atrial appendage occlusion have been confirmed by randomized controlled trials and actual experience. Among patients with different left atrial appendage emptying speeds, there are limited studies on the structure and function of the left atrial appendage after LAA closure. In this study, patients with persistent nonvalvular atrial fibrillation were selected for radiofrequency ablation combined with LAA closure. The sinus rhythm was restored after the operation. According to the different emptying speed of the left atrial appendage, they were divided into a high-flow rate group and a low-flow rate group. The differences in the structure and function of the left atrium between the two groups were analyzed.

Detailed Description

Not available

Study Timeline

• Status Verified: 2020-01
• Study Start: 2020-01-01
• Study First Submitted: 2020-12-10
• Study First Submitted QC: 2020-12-30
• Primary Completion: 2021-01-01
• Study Completion: 2021-01-01
• Study First Posted: 2021-01-05
• Last Update Submitted: 2021-03-17
• Last Update Posted: 2021-03-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients who received atrial fibrillation radiofrequency ablation combined with left atrial appendage closure.

Exclude Criteria

• Patients with incomplete data.
• Device embolism.
• Residual shunt around the device found by transesophageal echocardiography greater than 5 mm.
• Mitral valve stenosis.
• Artificial valve.
• Atrial septal defect.
• Dilated cardiomyopathy
• Moderate Severe mitral regurgitation

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
low-flow rate group	Transesophageal ultrasound	-
high-flow rate group	Transesophageal ultrasound	-

Primary Outcome Measures

Name	Time	Method
Changes in the structure of the left atrium	1year	Measure the left atrial transverse diameter, anteroposterior diameter, upper and lower diameter.
Changes in the function of the left atrium	1year	Left atrium volume. Two-chamber and four-chamber left atrium strain and strain rate, left atrium storage function, channel function and pump function.

Trial Locations

Locations (1)

The Second Hospital of Hebei Medical University; 🇨🇳 Shijiazhuang, Hebei, China