Molecular Pituitary Imaging Using 18F-FET PET

Not Applicable

Not yet recruiting

• Conditions: Pituitary Adenoma
• Interventions: Diagnostic Test: 18F-Fluoro-ethyl-tyrosine (FET) PET

• Registration Number: NCT06584123
• Lead Sponsor: University of Cambridge

Brief Summary

The goal of this single centre pilot study is to explore whether 18F-fluoro-ethyl-tyrosine PET (FET-PET) yields comparable findings to 11C-methionine PET (Met-PET) for the localisation of pituitary tumours.

Detailed Description

Up to 20 patients with pituitary adenomas (PA) who have previously undergone 11C-methionine PET (Met-PET) as part of routine clinical care will undergo 18F-fluoroethyltyrosine PET (FET-PET). Patients with newly diagnosed PA or residual/recurrent pituitary tumours following previous treatment will be eligible for recruitment to the study.

Quantitative and qualitative analyses will be performed to assess whether MET-PET and FET-PET yield comparable findings in patients with newly diagnosed or recurrent PA.

Study Timeline

• Study First Submitted: 2024-07-24
• Status Verified: 2024-08
• Study First Submitted QC: 2024-08-30
• Last Update Submitted: 2024-08-30
• Study Start: 2024-09-03
• Study First Posted: 2024-09-04
• Last Update Posted: 2024-09-04
• Primary Completion: 2026-09-02
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Study cohort	18F-Fluoro-ethyl-tyrosine (FET) PET	All patient's enrolled in the study will undergo an 18F-FET-PET

Primary Outcome Measures

Name	Time	Method
Maximum Standardized Uptake Values (SUVmax) over pituitary tumour on each of 11C-methionine and 18F-fluoroethyltyrosine PET scans	1 day	Comparison of maximum Standardized Uptake Values (SUVmax) measured over pituitary tumours on each type of PET scan.

Secondary Outcome Measures

Name	Time	Method
Maximum Standardized Uptake Values (SUVmax) over normal pituitary gland and parasellar structures (e.g. cavernous sinuses) on each of 11C-methionine and 18F-fluoroethyltyrosine PET scans	1 day	Comparison of maximum Standardized Uptake Values (SUVmax) measured over normal pituitary gland and parasellar structures (e.g. cavernous sinuses) on each type of PET scan.