Eccentric Cycling Exercise During Pulmonary Rehabilitation Pulmonary Vascular Disease
- Conditions
- Eccentric Cycling Exercise
- Interventions
- Procedure: normal rehabilitationProcedure: Rehabilitation with eccentric cycling exercise
- Registration Number
- NCT06480656
- Lead Sponsor
- University of Zurich
- Brief Summary
Eccentric cycling allows high intensities with low metabolic costs. Therefore the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with PVD
- Detailed Description
Eccentric cycling exercise (ECC) allows training at low metabolic costs and may therefore be valuable for patients with pulmonary vascular disease (PVD). For these patients, regular exercise training has an evidence level 1A recommendation in the current guidelines. Exercise training during longer and regular periods provides chronic adaptation, for which ECC was recently found to have a greater effectiveness than CON by increasing muscle strength, hypertrophy, six-minute walking distance and furthermore, by increasing maximum oxygen uptake (V'O2max) especially in patients with chronic obstructive pulmonary disease (COPD), chronic left heart failure or coronary heart disease.
Furthermore, the investigators conducted an RCT in which the investigators exposed patients with PVD to ECC and concluded that ECC is a feasible and well-tolerated exercise modality for PVD patients with severely lower O2 demand and load to the right ventricle.
Therefore the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with PVD.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 22
- Diagnosed with PVD, either PAH or CTEPH according to recent guidelines
- Stable medication for at least 1 month
- Age 18 to 85 years
- No resting hypoxemia (PaO2 >7.3kPa)
- Any co-morbidity that limits the patient to participate the full rehabilitation
- Enrollments in other trials with active treatments
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Concentric cycling exercise normal rehabilitation - Eccentric cycling exercise Rehabilitation with eccentric cycling exercise -
- Primary Outcome Measures
Name Time Method peak exercise capacity 3 weeks
- Secondary Outcome Measures
Name Time Method Arterial lactate concentration 3 weeks Arterial blood gas analyses, taken from the radial artery and analysed by radiometer
ventricular - pulmonary arterial coupling 3 weeks 6 minute walk distance 3 weeks systolic pulmonary artery pressure 3 weeks total pulmonary resistance 3 weeks cardiac output 3 weeks will be assessed by echocardiography using the pulse-wave doppler technique at the left ventricular outflow tract durig systole.
Borg CR 10 for perceived dyspnea 3 weeks Peak oxygen uptake 3 weeks Assesses during exercise until exhaustion using an incremental exercise protocol
ventilatory equivalent for CO2 3 weeks Arterial partial pressure for oxygen 3 weeks Arterial blood gas analyses, taken from the radial artery and analysed by radiometer
Arterial oxygen saturation 3 weeks Arterial blood gas analyses, taken from the radial artery and analysed by radiometer
Visual analogue scale generell well being 3 weeks Visual analogue scale dyspnea 3 weeks Finger pulseoximetry 3 weeks Arterial oxygen saturation will be assessed by finger clip Infrared spectroscopy
Borg CR 10 for perceived leg fatigue 3 weeks Arterial partial pressure for carbon dioxide 3 weeks Arterial blood gas analyses, taken from the radial artery and analysed by radiometer
Trial Locations
- Locations (2)
University Hospital Zurich, Pneumology
🇨🇭Zurich, Switzerland
Rehabilitation clinic Barmelweid
🇨🇭Erlinsbach, Switzerland