Mannitol inhalations as a new procedure for testing of airways hyperresponsiveness

Completed

Conditions: Bronchial hyperreactivity
chronic bronchitis
COPD
reaction of airways to stimuli that do not cause a reaction normallyhma
10006436

Registration Number: NL-OMON31934

Lead Sponsor: ongziekten

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 120

Inclusion Criteria

Asthmatics:
- Episodic symptoms of dyspnea, and/or wheezing, and/or cough
- Allergic or non-allergic
- non current smokers (> 0.5 years)
- PC20 MCh < 8 mg/ml;COPD patients:
- Age > 40 yrs
- Active or former smokers, with a smoking history of more than 10 packyears
- Continuous symptoms of cough/sputum and/or dyspnea on exertion
- No history of asthma
- FEV1/FVC < 70 % and FEV1 between 50 and 80 % pred.;Controls
- No history of asthma or COPD
- PC20 MCh > 8 mg/ml
- FEV1/FVC > 70 % and FEV1 > 90 %pred.

Exclusion Criteria

m- Age < 18 years
- Inability to perform acceptable-quality spirometry or to understand directions given by personnel
- Severe airflow limitation (FEV1 < 50% of predicted or < 1.0 L)
- Heart attack or stroke in last 6 months
- Uncontrolled hypertension, systolic BP > 200, or diastolic BP > 100
- Known aortic aneurysm
- Pregnancy
- Nursing mothers
- Current use of cholinesterase inhibitor medication (for myasthenia gravis)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Time involved in measurement of hyperresponsiveness (including technician time<br /><br>for preparation and cleaning)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Patient reported side effects<br /><br>- Patient preference<br /><br>- Technician preference<br /><br>- Borg score during test<br /><br>- BHR questionnaire (van der Molen 2005)</p><br>