Modulation of Lung Injury Complicating Lung Resection
- Registration Number
- NCT00655928
- Lead Sponsor
- Imperial College London
- Brief Summary
The purpose of this study is to determine whether N-acetylcysteine given intravenously 1 day pre-operatively is effective in preventing inflammation in the lungs, as measured by tests on blood, breath and lung specimens, in patients undergoing surgery to remove a portion of lung.
- Detailed Description
Acute lung injury occurs following lung resection in about 5% cases, and has a high mortality of around 50%. Management of these patients is largely supportive. Even in patients who do not develop clinical evidence of acute lung injury, markers of inflammation and oxidative stress are present in blood and exhaled breath condensate after lung resection. The purpose of this randomised double-blind placebo-controlled study is to determine whether lung injury can be prevented by pre-administration of N-acetylcysteine.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 52
- Elective lung resection for cancer
- Age less than 18 years
- Women of child-bearing age or potential
- Known allergy to N-acetylcysteine
- Oral steroid in the preceding 1 month
- N-acetylcysteine in the preceding 1 month
- Unable to receive standardised anaesthetic approach
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo 0.9% saline Participant received 0.9% saline 1 litre intravenous over 12 hours pre-operatively N-acetylcysteine N-acetylcysteine Participant received N-acetylcysteine 240mg/kg in 1 litre 0.9% saline intravenous over 12 hours pre-operatively
- Primary Outcome Measures
Name Time Method Post-operative Plasma IL-6 Post operative, 24 hours Plasma IL-6 was measured in duplicate using ELISA.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Royal Brompton Hospital
🇬🇧London, United Kingdom