The effect of optimization of the electrical synchronicity of both heart chambers on the blood flow and blood volumes in and around the heart, during and after a coronary bypass surgery, in patients with an impaired heart function based on asynchronous contraction of both heart chambers

Not Applicable

Completed

• Conditions: Circulatory System; Heart failure patients with ventricular dyssynchrony in cardiac surgery; cardiovascular monitoring and contrast-enhanced echocardiography; Heart failure

• Registration Number: ISRCTN90330260
• Lead Sponsor: Catharina Hospital Eindhoven (Catharina Ziekenhuis Eindhoven) (Netherlands)

Brief Summary

2015 results in https://pubmed.ncbi.nlm.nih.gov/25753598/ (added 29/05/2020)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-05-16
• Study Completion: 2015-01-01
• Last Update Posted: 8 June 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. Age 18 years or over
2. Patients scheduled for coronary artery bypass grafting surgery (CABG) and/or valve surgery
3. Left ventricular ejection fraction of 35% or less
4. Sinus rhythm with one of the following criteria:
4.1. QRS duration of > 130 ms and left bundle branch pattern
4.2. Pacemaker-dependent patients with right ventricular paced rhythm and QRS width of > 180 ms
4.3. Evidence of left ventricular dyssynchrony with Tissue Doppler Imaging (TDI)
5. Able to give informed consent

Exclusion Criteria

1. Myocardial infarction within the past 3 months
2. A history of gastric or esophageal disease
3. Allergy to sulphur hexafluoride

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in left ventricular pressures, pulmonary blood volume, intrathoracic blood volume and total circulating blood volume after biventricular pacing in comparison with the patient?s own rhythm and right ventricular pacing.

Secondary Outcome Measures

Name	Time	Method
Perioperative changes in hemodynamic performance after biventricular pacing.