Chocolate blood pressure lowering trial
Completed
- Conditions
- HypertensionPrehypertensionLifestyle intervention
- Registration Number
- NL-OMON24612
- Lead Sponsor
- Academic Medical CenterUniversity of AmsterdamThe Netherlands
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 42
Inclusion Criteria
1. Written informed consent
2. Age 40-70 years
Exclusion Criteria
1. Previous cardiovascular event(s) (stroke, TIA, angina, myocardial infarction, heart failure)
2. Total cholesterol > 8.0 mmol/L
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The difference in blood pressure between the placebo treatment arm and the cocoa treatment arms as assessed by 24-hour ambulatory blood pressure measurement.
- Secondary Outcome Measures
Name Time Method The difference between the placebo treatment arm and the cocoa treatment arms in:<br /><br>* Augmentation index, central (aortic) blood pressure and pulse wave velocity as assessed by the Sphygmocor device.<br /><br>* Systemic vascular resistance as assessed by Finapres.<br /><br>* Insulin sensitivity, lipid profile measured with standard laboratory techniques. <br /><br>* Platelet aggregation and function.<br /><br>* Mood and psychological well-being (via self-report questionnaires)<br>