Nalbuphine as an Adjuvant to Local Anaesthetic Mixture in Peribulbar Cataract Surgery a Randomized Controlled Study
Overview
- Phase
- Not Applicable
- Intervention
- Nalbuphine
- Conditions
- Nalbuphine as an Adjuvant to L. A in Peribulbar Block for Cataract Surgery
- Sponsor
- Cairo University
- Enrollment
- 40
- Locations
- 2
- Primary Endpoint
- Sensory block
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Nalbuphine has been used as an adjuvant to bupivacaine in intrathecal, epidural, caudal anesthesia and peripheral nerve blocks showing an increase in the efficacy and the duration of postoperative analgesia.The aim of this study is evaluation of the effect of nalbuphine when used as an adjuvant to a local anesthetic mixture in peribulbar block undergoing cataract surgery
Detailed Description
44 patients (22 in each group) scheduled for elective cataract surgery using peribulbar block. Patients of Group N received local anesthetics received 6 ml of 0.5% bupivacaine 1 ml hyaluronidase (75 IU), and 4mg of Nalbuphine in 1 ml of saline (total 8 ml) and patients of Group C received 6 ml of 0.5% bupivacaine, 1 ml hyaluronidase (75 IU) and1 ml saline (total 8 ml). Addition of nalbuphine to bupivacaine in peribulbar block is associated with reduced the time of onset of globe akinesia, increased the duration of globe akinesia and analgesia with better postoperative pain relief
Investigators
Ahmed Abdalla
Assistant Professor of Anesthesia&I.C.U and Pain Clinic
Cairo University
Eligibility Criteria
Inclusion Criteria
- •patients aged 40-60 years.
- •both sex.
- •ASA physical status Ι\&II.
- •Patient with axial globe length below 26
Exclusion Criteria
- •Refusal of the patient to participate in the study.
- •Coagulation abnormalities(INR\>1.4).
- •More than ASA II.
- •High myopia with axial length more than 26 mm.
- •Mentally retarded patients and failure of proper communication as in deafness .
- •Morbidly obese patients(BMI\>35)
- •Patients with glaucoma (increased IOP\>20mmgh)
- •Patients with history of hypersensitivity to study drugs
Arms & Interventions
Group N
group N was received a mixture of 3 ml of 2% lidocaine, 4 ml of 0.5% bupivacaine with hyaluronidase (75IU) and 4mg of nalbuphine in 1 ml normal saline. Nalbuphine (20mg amp.) was prepared in 0.9% sodium chloride in 5mL syringe. If the block was inadequate after 10 minutes, a 2-4 ml supplementation of local anesthetics was given by the same technique and the patient was excluded from the study
Intervention: Nalbuphine
Group N
group N was received a mixture of 3 ml of 2% lidocaine, 4 ml of 0.5% bupivacaine with hyaluronidase (75IU) and 4mg of nalbuphine in 1 ml normal saline. Nalbuphine (20mg amp.) was prepared in 0.9% sodium chloride in 5mL syringe. If the block was inadequate after 10 minutes, a 2-4 ml supplementation of local anesthetics was given by the same technique and the patient was excluded from the study
Intervention: lidocaine, bupivacaine , hyaluronidase
Group C
Patients of group C was received a mixture of 3 ml of 2% lidocaine, 4 ml of 0.5% bupivacaine with hyaluronidase (75 IU) and 1 ml normal saline
Intervention: lidocaine, bupivacaine, hyaluronidase , saline
Outcomes
Primary Outcomes
Sensory block
Time Frame: 12 hours Postoperative
Duration of the sensory block
Secondary Outcomes
- Sensory block onset(12 hours Postoperative)
- Adverse effects of the used drugs(24 hours postoperatively)
- Satisfaction assessed at the end of surgical procedure by using a three-point scale(6 hours Postoperative)
- Motor block(12 hours Postoperative)
- Mean Arterial blood pressure(24 hours postoperatively)