Effects of N-3 Polyunsaturated Fatty Acids Enriched Chicken Meet on Cardiovascular Function
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Microvascular endothelial function
研究概览
简要总结
Evidence from multiple experimental, epidemiological, and clinical studies indicate that n-3 polyunsaturated fatty acids (n-3 PUFAs) may exert their cardiovascular (CV) protective effect, at least in part, by improving vascular endothelium-dependent function. Previously, the investigators demonstrated the significant beneficiary effect of consumption of n-3 PUFA-enriched hen eggs on microvascular endothelium-dependent reactivity, even in young healthy individuals.
The hypothesis of this research is that the consumption of n-3 PUFAs in the form of functionally enriched chicken meet has a beneficial effect on vascular reactivity measured in different vascular beds, and the lipid profile with a positive effect on the reduction of oxidative stress and inflammatory response in healthy sedentary individuals.
The main goal of this study is to investigate the influence of n-3 PUFAs functionally enriched chicken meet on vascular and endothelial function in a population of healthy young subjects and active athletes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 39 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •young healthy sedentary individuals - did not perform regular physical activities for at least 12 months before conducting the study
- •young healthy active athletes - have a minimum of 5 training sessions per week (mainly endurance training) for at least 12 months prior to conducting the study
排除标准
- •hypertension
- •coronary disease
- •hyperlipidemia
- •kidney damage
- •cerebrovascular and peripheral artery diseases
- •and any other disease that could have an impact on vascular and endothelial function
结局指标
主要结局
Microvascular endothelial function
时间窗: 3 weeks
Cutaneous microvascular blood flow will be measured by Laser Doppler Flowmetry in response to vascular occlusion (post occlusive reactive hyperaemia - PORH), in response to iontophoresis of acetylcholine (ACh) and local thermal hyperemia (LTH).
Cerebrovascular reactivity
时间窗: 3 weeks
Measurement of cerebrovascular blood flow using transcranial color Doppler (TCD).
Macrovascular endothelial function
时间窗: 3 weeks
Measurement of flow mediated dilation (FMD) of brachial artery using ultrasound.
次要结局
- Serum Pro- and Anti-Inflammatory Cytokines, Chemokines, Growth Factors and Soluble Cell Adhesion Molecules Protein Concentration(3 weeks)
- Lipid profile(3 weeks)
- Systemic hemodynamics(3 weeks)
- Body composition(3 weeks)
- Body fluid status(3 weeks)
- Oxidative stress status(3 weeks)
研究者
Ines Drenjancevic
Vice Dean for Science, Faculty of Medicine Josip Juraj Strossmayer University of Osijek
Josip Juraj Strossmayer University of Osijek