T cell function in acute hepatitis B virus infectio

Completed

• Conditions: 10019654; 10047438; acute liver infection with hepatitis B virus; acute viral infection with hepatitis B virus

• Registration Number: NL-OMON38638
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Patients that will be included are:
- patients who present to the AMC or to the AMC outpatient clinic location GG&GD Amsterdam with an acute hepatitis B infection;
- patients formerly diagnosed (at the AMC) with an acute HBV infection (within the last 5 years) and from whom blood samples for viral diagnostics at several time points were collected.

Exclusion Criteria

Unwillingness to donate blood and/or sign an informed consent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary objective: to define the immunologic and virologic signature of acute<br /><br>hepatitis B patients by longitudinally studying the phenotypic and functional<br /><br>characteristics of peripheral blood mononuclear cells (PBMC*s) and HBV viral<br /><br>kinetics. Patients with acute HBV infection will be compared to patients with<br /><br>chronic HBV infection (with high and low viral load).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary objective: to investigate the mechanism of development of chronic HBV<br /><br>infection by comparing patients with acute HBV infection in patients clearing<br /><br>the HBV within 6 months versus patients who develop chronic HBV infection.</p><br>