Prospective Cohort Study on Cognition and Cardiovascular Disease of Sedentary Behaviors in Children
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 1,000
- 主要终点
- Self-reported physical activity and sedentary lifestyle.
研究概览
简要总结
The prospective cohort study is set up to address research questions dealing with sedentary lifestyle-related events mainly including cognition and cardiovascular-related disease in children .Participants aged 7-12 years old from five primary schools in Guangzhou,Guangdong province will be recruited and followed up to evaluate the risk factors of cognition and cardiovascular-related disease. Objective measurements combined with questionnaire-data-based information on a wide range of lifestyle factors and cognition were applied in this study.
详细描述
There are three stages in this project.At first stage,information about socio-demographic, psychological status, physical activity,sleep and diet were collected by a multi-components questionnaire survey.The Strengths and Difficulties Questionnaire(SDQ) and Behavior Rating Inventory of Executive Function(BRIEF) were conducted at the same time. Anthropometric measurement including height, weight, waist and hip circumferences, blood pressure and fat mass were conducted.Besides,blood samples were collected to measure total cholesterol, triglycerides, high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C).
At second stage,participants were classified for 4 subgroups as follows: Low active-high sedentary;low active-low sedentary; high active-high sedentary;high active-low sedentary by different sedentary status and physical activity levels according to the international standard. Later cardiorespiratory fitness was assessed by the 20-m shuttle run test. Accelerometer GT3X+ Actigraph with physical activity log,Combined Raven's test, a series of psychometric paradigms were measured for further studies.
At third stage,we will explore the related neuropsychological mechanism using the technology of event-related potentials (ERPs).
About 1000 participants (7-12 years old) will be prospectively followed up. The associations between sedentary lifestyle and risks for cognition and cardiovascular-related disease will be evaluated.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 7 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •7-12 years old
- •Children with normal intelligence measured by Raven Good vision.
- •Right hand.
排除标准
- •Children with mental health and behavioral problems in this study were found to have developmental behavior disorders, such as ADHD, ASD.
- •There are serious liver and kidney diseases, cardiovascular diseases, hematologic diseases or malignant tumors.
结局指标
主要结局
Self-reported physical activity and sedentary lifestyle.
时间窗: 2017.01-2026.12
Using International Physical Activity Questionnaire-Short-Chinese（IPAQ-S-C）to assess the frequency and duration of activity and sedentary lifestyle（SL） in the last 7 days .Subjects with moderate activity and vigorous activity(MVPA)≥60min/day were classified into high PA subgroup while those with MVPA\<150min/week were classified into low PA subgroup according to the international standard.Subjects with SL≥gender-, age-specific 75% percentile were assigned to the high SL subgroup and\< gender-, age-specific 25% percentile were assigned to the low SL subgroup.
次要结局
- Stroop task(2017.01-2026.12)
- Biochemical indicator(2017.01-2026.12)
- Anthropometric(2017.01-2026.12)
- Cardiorespiratory Fitness(CRF)(2017.01-2026.12)
- Combined Raven's Test(2017.01-2026.12)
- Self-reported cognition(2017.01-2026.12)
- Corsi block-tapping task(2017.01-2026.12)
- Objective measurement of physical activity and sedentary lifestyle.(2017.01-2026.12)
- Wisconsin Card Sorting Test(WCST)(2017.01-2026.12)
- Event-related potentials(2018.09-2026.12)
研究者
CHEN Yajun
Associate Professor
Sun Yat-sen University