Four dimensional flow analysis of complex congenital heart disease

Completed

• Conditions: arterial switch circulation; Transposition of the great arteries; 10010394; 10007510

• Registration Number: NL-OMON48789
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 90

Inclusion Criteria

Patients < 16 years of age:
- Patients with a transposition of the great arteries who underwent an arterial
switch operation
- Patients aged > 7 years
- Patients with a clinical indication for CMR, echocardiography and
cardiopulmonary exercise
testing per order of the treating clinician

Patients > 16 years of age:
- Patients with a transposition of the great arteries who underwent an arterial
switch operation
- Patients aged 16-40 years

Exclusion Criteria

Minors under the age of 8 years

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>* The ICC of 2D-PC CMR stroke volume measurements in the MPA and multi-slice<br /><br>volumetric RV flow volume<br /><br>* The ICC of 4D-flow CMR measurements in the MPA and multi-slice volumetric RV<br /><br>flow volume measurements</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>o Net flow (mL/cycle)<br /><br>o Retrograde flow (%)<br /><br>o Peak flow (mL/s)<br /><br>o Time-to-peak flow (ms)<br /><br>o Peak acceleration (L/s²)<br /><br>o Resistance index<br /><br>o Wall shear stress (Pa).<br /><br>o Pressure difference (mmHg).<br /><br>o Pulse wave velocity (m/s).<br /><br>o Turbulent kinetic energy (mW).<br /><br>o Viscous energy losses (mW).<br /><br>o Peak velocity (m/s).</p><br>