Randomized controlled trial of respiratory muscle training after a pleurodesis for malignant pleural effusio

Not Applicable

• Conditions: Malignant Pleural Effusion; Respiratory - Other respiratory disorders / diseases; Cancer - Any cancer

• Registration Number: ACTRN12615000841572
• Lead Sponsor: Dr Luke Garske

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-08-13
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

1. Malignant Pleural Effusion (defined as fluid around lung caused by cancer infiltrating the pleura): diagnosed on basis of (a) pleural fluid cytology or biopsy, or (b) a large exudative pleural effusion with no other cause identified and disseminated extra-thoracic malignancy.
2. Participants have undergone a pleurodesis 3 weeks prior to study entry. Pleurodesis may be either surgical (VATS or thoracoscopy) or closed chest tube pleurodesis.
3. No significant fluid re-accumulation on clinical assessment 3 weeks after a pleurodesis.

Exclusion Criteria

Expected survival < 3 months
WHO performance status 3 or 4
Body mass index less than 19 or greater than 40
Hypoxia requiring long term oxygen therapy
Severe cardiac or pulmonary disease causing dyspnea
Neurologic disease which may affect respiratory muscle strength, or co-operation with testing
Long term steroid therapy
Significant chest pain which might interfere with breathing tests and training
Pleural tumour greater than 20 mm thickness on CT chest
Recent pneumothorax
Severe osteoporosis (t score <-3.5), or history of spontaneous rib fractures
Rib metastasis
Chest wall deformity (kyphoscoliosis)
Perforated ear drum or symptoms of eustachian tube insufficiency
Language barrier or other significant communication difficulty
Women who are pregnant

Study & Design

• Study Type: Interventional
• Study Design: Not specified