A study on the effect of gastric bypass on the absortpion of metoprolol immediate release tablet.

• Conditions: Roux- en-Y gastric bypass; <br />Metoprolol<br />immediate release tabletabsorptiongastric bypassmetoprololdirecte afgifte tabletabsorptie

• Registration Number: NL-OMON29306
• Lead Sponsor: Medisch Centrum Leeuwarden

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

Female gender;

- Age 18-50 years;

Exclusion Criteria

- Pregnancy;

- Smoking;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Parameters that will be determined before and after surgery are Cmax, Tmax, and<br>AUC0-10 of metoprolol and its main active metabolite &#945;-OH metoprolol.<br><br>The main endpoint is the ratio of AUCafter/AUCbefore of metoprolol and &#945;-OH metoprolol.

Secondary Outcome Measures

Name	Time	Method
Secondary endpoint is the quotient of the ratios of the AUC of metoprolol and its metabolite after and before.<br><br><br>Other study parameters<br>Blood pressure and heart rate measured at t = 0, 2, 4, 8 and 10 hours after intake of metoprolol.<br><br>Further analysis<br>After completion of the other pharmacokinetic study with metoprolol controlled release tablet relevant parameters may be compared for further analysis.