The Effects of Intravenous Anesthetics on QT interval during Anesthetic Induction with Desflurane
- Conditions
- The patients who undergo lumbar surgery
- Registration Number
- JPRN-UMIN000023707
- Lead Sponsor
- agasaki Rosai Hospital Medical Office
- Brief Summary
Fifty-three patients, 38male and 15female, were enrolled in the study. Of these, 3 patients (2 male, 1 from each group, and 1 female from Group T were excluded because their ECG data were wrongly entered in the software. Therefore, 50 patients were included in the final analysis.There were no significant differences between the 2 groups. There were no significant differences in ETdes between the 2 groups. BIS and MAP were significantly decreased after anesthesia induction in both groups. MAP in Propofol group was lower than Thiamylal group after anesthesia induction. There were no significant differences in HR and QTcD at any recorded time point. In Group P, the QTc interval values at T3 was significantly shortened compared with the QTc interval at T1. In Group T, the QTc interval values at T4 and T5 were significantly prolonged compared with the QTc interval at T1. The QTc intervals at T3, T4 and T5 in Group T were significantly longer than those in Group P.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 50
Not provided
1.heart disease 2.arrhythmia 3.antiarrhythmia drug 4.antipsychotic drug 5.hypo/hyper kalemia(<3.5mEq/L, >5.5mEq/L) 6.asthma 7.BMI>30
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method QT interval time from pre-induction to after intubation
- Secondary Outcome Measures
Name Time Method