Screening for Colorectal Cancer in Recipients of Kidney Transplants

Not Applicable

Completed

• Conditions: Kidney Transplantation - post transplant malignancy; Colorectal Cancer; Cancer - Bowel - Back passage (rectum) or large bowel (colon)

• Registration Number: ACTRN12608000154303
• Lead Sponsor: Dr Michael Collins

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-04-02
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 450

Inclusion Criteria

Kidney transplant recipients in South Australia >=50 years old, more than 6 months post transplant
- Willing and able to give informed consent

Exclusion Criteria

- Active unstable cardiopulmonary disease
- Terminal illness, life threatening malignancy
- Bleeding disorders or unable to stop oral anti-coagulants for colonoscopy
- Colonoscopy within 12 months prior to enrolment
- Failed kidney transplant and return to dialysis prior to enrolment
- Symptoms or signs suggestive of colorectal cancer
- Previous personal history of colorectal cancer, advanced adenoma or chronic ulcerative colitis
- Family history of Familial Adenomatous Polyposis (FAP) or Hereditary non-polyposis colorectal cancer (HNPCC)

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sensitivity and specificity of faecal occult blood testing for colorectal cancer and colorectal neoplasia, using colonscopy as the gold standard procedure.[One-off screening with both FOBT and colonoscopy, with a completion target of 3 months post enrolment.]

Secondary Outcome Measures

Name	Time	Method
Rate of Colorectal Cancer and colorectal neoplasia found at screening colonoscopy.[One-off screening colonoscopy, with a completion target of 3 months post enrolment.]