The influence of hemodialysis and vascular access surgery on systemic circulation and microcirculation: a validation study
- Conditions
- DialysisHemodialysis100291491000318410047066
- Registration Number
- NL-OMON48972
- Lead Sponsor
- Haaglanden Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
All subjects must be able to participate and be willing to give written informed consent and to comply with the study restrictions. In addition, eligible subjects must meet the following inclusion criteria:;- Patients male/female > 18 years old that are on hemodialysis using an arteriovenous fistula (AVF) or arteriovenous graft ( AVG) and are capable of giving written informed consent.
1. Concomitant disease or condition that could interfere with the conduct of the study or the study objectives, or that would, in the opinion of the investigator, pose an unacceptable risk to the study participant.
2. Condition of the skin that prohibits accurate LSCI measurements, such as large tattoos, skin ulcers, scar tissue, etc.
3. For group 2: prior vascular access surgery on contra or ipsilateral arm.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>* correlation of finger and toe pressures with LSCI and shuntflow measurements</p><br>
- Secondary Outcome Measures
Name Time Method <p>* Variability of microcirculation measured with LSCI in hemodialysis patients.<br /><br>* Association between shuntflow and basal blood flow measured with<br /><br>microcirculation measurements using LSCI<br /><br>* * LSCI (blood flow upon occlusion/reperfusion) and shunt flow<br /><br>* Effect of a hemodialysis session on finger and toe pressures and LSCI basal<br /><br>blood flow<br /><br>* Correlation between blood flow upon occlusion/reperfusion ( endothelial<br /><br>function) using LSCI in hemodialysis patients and retrospective good/poor AVF<br /><br>maturation.</p><br>