The effect of Montelukast on respiratory complications detected in patients with multiple trauma and lung injury

Phase 2

Recruiting

Conditions: Condition 1: Contusion of lung. Condition 2: Multiple fractures of ribs. Condition 3: Acute respiratory distress syndrome. Condition 4: Pneumonia. Condition 5: Pulmonary embolism.
Contusion of lung
Multiple fractures of ribs
Acute respiratory distress syndrome
Streptococcus pneumoniae as the cause of diseases classified elsewhere
Pulmonary embolism
S27.32
S22.4
B95.3

Registration Number: IRCT20190719044270N1

Lead Sponsor: Bagheiat-allah University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

Patients with blunt multiple trauma and at least 3 fractured ribs
Patients with blunt multiple trauma and lung contusion detected in CT scan performed on arrival

Exclusion Criteria

Patients younger than 16 years
Patients with penetrating trauma
Patients with history of cardiopulmonary disease
Patients with history of hypersensitivity to Montelukast
Patients who will not sign the informed written consent

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ung contusion. Timepoint: on day 0 and 7. Method of measurement: Chest CT-scan.;Acute Lung Injury. Timepoint: on day 7. Method of measurement: Chest CT-scan.;Acute Respiratory Distress Syndrome. Timepoint: on day 7. Method of measurement: Chest CT-scan.;Pulmonary Emboli. Timepoint: on day 7. Method of measurement: Chest CT angiography.;Pneumonia. Timepoint: on day 7. Method of measurement: Chest CTscan.

Secondary Outcome Measures

Name	Time	Method
C reactive Protein. Timepoint: day 0 and 3. Method of measurement: Serum agglutination test.;Procalcitonin. Timepoint: day 3. Method of measurement: Blood level of procalcitonin.;Length of ICU stay. Timepoint: Discharge from ICU. Method of measurement: counting ICU admission days.;Days underwent ventilator assisted respiration. Timepoint: on discharge. Method of measurement: counting the days underwent ventilator assisted respiration.