Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treated c-Met+ Non-Small Cell Lung Cancer
- Conditions
- Non-small Cell Lung Cancer
- Interventions
- Registration Number
- NCT03539536
- Lead Sponsor
- AbbVie
- Brief Summary
This study is designed to identify the target Non-Small Cell Lung Cancer (NSCLC) population(s) that overexpress c-Met (c-Met+) best suited for telisotuzumab vedotin therapy in the second line or third line setting (Stage 1) and then to expand the group(s) to further evaluate efficacy in the selected population(s) (Stage 2). After the Stage 2 global enrollment is completed, an additional cohort at an alternate dose level will evaluate the safety and efficacy of telisotuzumab vedotin (Stage 3).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 270
- Have locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Have c-Met+ NSCLC as assessed by an AbbVie designated immunohistochemistry (IHC) laboratory. Participant must submit archival or fresh tumor material for assessment of c-Met levels during the prescreening period. Tumor material from the primary tumor site and/or metastatic sites are allowed. If archival tissue is negative for c-Met overexpression, subject can submit fresh biopsy material for reassessment of c-Met expression.
- Histologically documented non-squamous epidermal growth factor receptor (EGFR) wild type NSCLC (site documented EGFR status). Of note, subjects with other actionable mutations are eligible as long as EGFR status is known and all other eligibility criteria are met. As of Protocol Version 11, Stage 1 is complete and Stage 2 is enrolling participants with non-squamous EGFR wild type NSCLC only.
- Must have received no more than 2 lines of prior systemic therapy (including no more than 1 line of systemic cytotoxic chemotherapy) in the locally advanced or metastatic setting.
- Multiple lines of tyrosine kinase inhibitors (TKIs) targeting the same tyrosine kinase (TK) count as 1 line of therapy for the purposes of this eligibility criterion.
- Progressed on systemic cytotoxic therapy (or are ineligible for systemic cytotoxic chemotherapy) and an immune checkpoint inhibitor (as monotherapy or in combination with systemic cytotoxic chemotherapy, or ineligible), and prior anticancer therapies targeting driver gene alterations (if applicable).
- Have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1.
- Treatment with any therapies within the noted time intervals is excluded prior to the first dose of telisotuzumab vedotin as noted in the protocol.
- Metastases to the central nervous system (CNS) are eligible only after definitive therapy (such as surgery or radiotherapy) is provided within the protocol.
-
Have received radiation therapy to the lungs < 6 months prior to the first dose of telisotuzumab vedotin.
-
Have received any live vaccine within 30 days of the first dose of investigational product.
-
Has adenosquamous histology.
-
Have a history of other malignancies except those noted within the protocol.
-
Have a history of interstitial lung disease (ILD) or pneumonitis that required treatment with systemic steroids.
-
Have any evidence of pulmonary fibrosis on screening imaging assessment or any history of pneumonitis or ILD within 3 months of the planned first dose of the study drug (Except for Sites in Ireland). For imaging findings deemed clinically insignificant by the treating physician, subject may be eligible after discussion with and approval from the AbbVie medical monitor.
-
For Sites in Ireland Only: Must not have any evidence of pulmonary fibrosis on screening imaging assessment or any history of pneumonitis or ILD. For imaging findings deemed clinically insignificant by the treating physician, subject may be eligible after discussion with and approval from the AbbVie medical monitor.
-
Have a clinically significant condition(s) as noted in the protocol.
-
Have unresolved clinically significant adverse events of Grade >= 2 from prior anticancer therapy, except for alopecia or anemia.
-
Have had major surgery within 21 days prior to the first dose of telisotuzumab vedotin.
-
For Sites in France and Czech Republic Only: Have the following:
- Known human immunodeficiency virus (HIV) infection. Note: HIV testing is not required for eligibility for this protocol unless mandated by local regulatory authority or ethics committee/institutional review board.
- Active hepatitis B virus (HBV) infection, defined by hepatitis B surface antigen (HBsAg) positivity or HBV DNA >= 500 IU/mL. In participants with known HBV infection, the presence of active infection must be tested locally. If HBV status is unknown, it must be tested locally at screening.
- Active hepatitis C virus (HCV) infection, defined by HCV ribonucleic acid (RNA) positivity. Participants cured of HCV infection may be included in the study. In participants with known HCV infection, the presence of active infection must be tested locally. If HCV status is unknown, it must be tested locally at screening.
- Uncontrolled autoimmune disease.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Telisotuzumab vedotin Telisotuzumab vedotin Telisotuzumab vedotin administered via intravenous (IV) infusion every 14 days.
- Primary Outcome Measures
Name Time Method Number of Participants with Adverse Events (Alternate dose cohort) Up to approximately 3 years An adverse event (AE) is defined as any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment.
Overall Response Rate (ORR) (Stage 1 and Stage 2) Up to approximately 3 years ORR is defined as the percentage of participants with a confirmed complete response (CR) or confirmed partial response (PR) based on Response Evaluation Criteria in Solid Tumors (RECIST), version 1.1.
- Secondary Outcome Measures
Name Time Method Duration of Response (DoR) (Stage 1 and Stage 2) Up to approximately 3 years DoR is defined as the time from the participant's initial response (CR or PR) to the first occurrence of radiographic progression determined by an independent central review or death from any cause for the responders.
Overall Survival (OS) (Stage 1 and Stage 2) Up to approximately 3 years OS is defined as the time from the participant's first dose of study drug until death from any cause.
Progression-Free Survival (PFS) (Stage 1 and Stage 2) Up to approximately 3 years PFS is defined as the time from the participant's first dose of study drug until the first occurrence of radiographic progression determined by an independent central review or death from any cause.
Disease Control Rate (DCR) (Stage 1 and Stage 2) Up to approximately 3 years DCR is defined as the percentage of participants with best overall response of confirmed CR, confirmed PR, or stable disease (SD) for at least 12 weeks following enrollment, based on RECIST, version 1.1.
Trial Locations
- Locations (252)
Veterans Healthcare System /ID# 215602
🇺🇸Pittsburgh, Pennsylvania, United States
Massachusetts General Hospital /ID# 203215
🇺🇸Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center /ID# 208124
🇺🇸Boston, Massachusetts, United States
Dana-Farber Cancer Institute /ID# 203248
🇺🇸Boston, Massachusetts, United States
University of Washington /ID# 206056
🇺🇸Seattle, Washington, United States
Anhui Chest Hospital /ID# 239048
🇨🇳Hefei, Anhui, China
Fujian Provincial Cancer Hospital /ID# 210808
🇨🇳Fuzhou, Fujian, China
Capital Health Medical Center /ID# 203403
🇺🇸Pennington, New Jersey, United States
Institut Gustave Roussy /ID# 205149
🇫🇷Villejuif Cedex, Val-de-Marne, France
Kurume University Hospital /ID# 227776
🇯🇵Kurume-shi, Fukuoka, Japan
Evimed Clinic /ID# 216473
🇷🇺Chelyabinsk, Russian Federation
Clinical Oncology Dispensary of Omsk /ID# 239313
🇷🇺Omsk, Russian Federation
Kaohsiung Chang Gung Memorial Hospital /ID# 205423
🇨🇳Kaohsiung City, Kaohsiung, Taiwan
Taipei Medical University Shuang Ho Hospital /ID# 215356
🇨🇳New Taipei City, Taiwan
MHAT Dobrich /ID# 230074
🇧🇬Dobrich, Bulgaria
Hirosaki University Hospital /ID# 245023
🇯🇵Hirosaki-shi, Aomori, Japan
Osaka International Cancer Institute /ID# 210735
🇯🇵Osaka-shi, Osaka, Japan
Spitalul Municipal Ploiesti /ID# 229097
🇷🇴Ploiesti, Prahova, Romania
Atlantic Health System /ID# 203404
🇺🇸Morristown, New Jersey, United States
Institut Curie /ID# 207046
🇫🇷Paris CEDEX 05, Paris, France
The Chaim Sheba Medical Center /ID# 204254
🇮🇱Ramat Gan, Tel-Aviv, Israel
National Hospital Organization Shikoku Cancer Center /ID# 232252
🇯🇵Matsuyama-shi, Ehime, Japan
Yokohama Municipal Citizen's Hospital /ID# 248374
🇯🇵Yokohama-shi, Kanagawa, Japan
Oncomed SRL /ID# 205616
🇷🇴Timisoara, Romania
Central Maine Medical Center /ID# 216583
🇺🇸Lewiston, Maine, United States
CISSS de la Monteregie /ID# 211356
🇨🇦Greenfield Park, Quebec, Canada
Chiba University Hospital /ID# 232204
🇯🇵Chiba-shi, Chiba, Japan
National Hospital Organization Kyushu Cancer Center /ID# 206061
🇯🇵Fukuoka-shi, Fukuoka, Japan
Saitama Cancer Center /ID# 232508
🇯🇵Kitaadachi-gun, Saitama, Japan
Med Polonia Sp. z o. o. /ID# 229908
🇵🇱Poznan, Wielkopolskie, Poland
Regional Children's Clinical Hospital of Volgograd /ID# 206520
🇷🇺Volgograd, Volgogradskaya Oblast, Russian Federation
Taichung Veterans General Hospital /ID# 205308
🇨🇳Taichung, Taiwan
Cross Cancer Institute /ID# 204540
🇨🇦Edmonton, Alberta, Canada
Institut Bergonie /ID# 216207
🇫🇷Bordeaux, Gironde, France
Hattiesburg Clinic /ID# 227691
🇺🇸Hattiesburg, Mississippi, United States
National Taiwan University Hospital /ID# 205100
🇨🇳Taipei City, Taiwan
Bioclinic Thessaloniki /ID# 227261
🇬🇷Thessaloniki, Greece
National Cheng Kung University Hospital /ID# 205307
🇨🇳Tainan, Taiwan
Linkou Chang Gung Memorial Hospital /ID# 205424
🇨🇳Taoyuan City, Taiwan
Nottingham University Hospitals NHS Trust /ID# 231224
🇬🇧Nottingham, Nottinghamshire, United Kingdom
Koo Foundation Sun Yat-Sen Cancer Center /ID# 227336
🇨🇳Taipei, Taiwan
LLC Medical Center /ID# 212397
🇷🇺Novosibirsk, Novosibirskaya Oblast, Russian Federation
Republican Clinical Oncology Dispensary /ID# 206463
🇷🇺Kazan, Tatarstan, Respublika, Russian Federation
Oxford University Hospitals NHS Foundation Trust /ID# 205890
🇬🇧Oxford, Oxfordshire, United Kingdom
Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 211119
🇨🇳Wuhan, Hubei, China
Jilin Cancer Hospital /ID# 210563
🇨🇳Changchun, Jilin, China
University of California, Los Angeles /ID# 203219
🇺🇸Los Angeles, California, United States
Highlands Oncology Group, PA /ID# 215600
🇺🇸Springdale, Arkansas, United States
Rocky Mountain Cancer Centers /ID# 215789
🇺🇸Lone Tree, Colorado, United States
Icri /Id# 227835
🇺🇸Whittier, California, United States
AdventHealth Celebration /ID# 215649
🇺🇸Celebration, Florida, United States
Straub Clinic and Hospital /ID# 217905
🇺🇸Honolulu, Hawaii, United States
Ingalls Memorial Hosp /ID# 203228
🇺🇸Harvey, Illinois, United States
The University of Chicago Medical Center /ID# 203216
🇺🇸Chicago, Illinois, United States
NorthShore University HealthSystem /ID# 215583
🇺🇸Evanston, Illinois, United States
Baptist Health /ID# 203283
🇺🇸Lexington, Kentucky, United States
Goshen Center for Cancer Care /ID# 215584
🇺🇸Goshen, Indiana, United States
Univ Kansas Med Ctr /ID# 216804
🇺🇸Kansas City, Kansas, United States
Cancer Center of Kansas /ID# 203235
🇺🇸Wichita, Kansas, United States
Henry Ford Hospital - West Bloomfield /ID# 203220
🇺🇸West Bloomfield, Michigan, United States
St. Vincent Frontier Cancer Center /ID# 203292
🇺🇸Billings, Montana, United States
Titan Health Partners LLC, d/b/a Astera Cancer Care /ID# 228868
🇺🇸East Brunswick, New Jersey, United States
University of New Mexico /ID# 208339
🇺🇸Albuquerque, New Mexico, United States
Overlook Medical Center /ID# 211160
🇺🇸Summit, New Jersey, United States
Mercy Cancer Center /ID# 231972
🇺🇸Elyria, Ohio, United States
Penn State University and Milton S. Hershey Medical Center /ID# 221844
🇺🇸Hershey, Pennsylvania, United States
Allegheny General Hospital /ID# 215585
🇺🇸Pittsburgh, Pennsylvania, United States
Houston Methodist Hospital - Scurlock Tower /ID# 213268
🇺🇸Houston, Texas, United States
Baylor Scott & White Medical Center- Temple /ID# 216578
🇺🇸Temple, Texas, United States
Thompson Cancer Survival Ctr /ID# 228874
🇺🇸Knoxville, Tennessee, United States
Virginia Cancer Specialists - Fairfax /ID# 203224
🇺🇸Fairfax, Virginia, United States
Valley Medical Center /ID# 231459
🇺🇸Renton, Washington, United States
Newcastle Private Hospital /ID# 206600
🇦🇺Lambton Heights, New South Wales, Australia
The Kinghorn Cancer Centre /ID# 207666
🇦🇺Darlinghurst, New South Wales, Australia
St John Of God Subiaco Hospital /ID# 226943
🇦🇺Subiaco, Western Australia, Australia
Universitair Ziekenhuis Antwerpen /ID# 217430
🇧🇪Edegem, Antwerpen, Belgium
Mater Misericordiae Limited /ID# 229639
🇦🇺South Brisbane, Queensland, Australia
Hospital La Louviere Site Jolimont - Helora /ID# 230586
🇧🇪La Louvière, Hainaut, Belgium
Vitaz /Id# 239966
🇧🇪Sint-Niklaas, Oost-Vlaanderen, Belgium
Institut Jules Bordet /ID# 238614
🇧🇪Anderlecht, Belgium
Jessa Ziekenhuis /ID# 234047
🇧🇪Hasselt, Belgium
AZ Maria Middelares /ID# 233474
🇧🇪Gent, Belgium
AZ Groeninge /ID# 217431
🇧🇪Kortrijk, Belgium
CHU de Liege /ID# 230589
🇧🇪Liege, Belgium
CHU UCL Namur - Sainte Elisabeth /ID# 234048
🇧🇪Namur, Belgium
Acibadem City Clinic Tokuda University Hospital EAD /ID# 232010
🇧🇬Sofia, Bulgaria
Ottawa Hospital Research Institute /ID# 205579
🇨🇦Ottawa, Ontario, Canada
UMHAT Dr Georgi Stranski EAD /ID# 232024
🇧🇬Pleven, Bulgaria
The First Affiliated Hospital of Guangzhou Medical University /ID# 232261
🇨🇳Guangzhou, Guangdong, China
Anhui Provincial Cancer Hospital /ID# 239058
🇨🇳Hefei, Anhui, China
Anhui Provincial Hospital /ID# 212096
🇨🇳Hefei, Anhui, China
Princess Margaret Cancer Centre /ID# 204423
🇨🇦Toronto, Ontario, Canada
Beijing Cancer Hospital /ID# 210133
🇨🇳Beijing, Beijing, China
Guangxi Medical University Cancer Center /ID# 231560
🇨🇳Nanning, Guangxi, China
Henan Cancer Hospital /ID# 210961
🇨🇳Zhengzhou, Henan, China
The First People's Hospital of Changzhou /ID# 210787
🇨🇳Changzhou, Jiangsu, China
Shandong Cancer Hospital /ID# 231577
🇨🇳Jinan, Shandong, China
Shanghai Chest Hospital /ID# 210930
🇨🇳Shanghai, Shanghai, China
The Affiliated Cancer Hospital of Xinjiang Medical University /ID# 227244
🇨🇳Urumqi, Xinjiang, China
West China Hospital, Sichuan University /ID# 210022
🇨🇳Chengdu, Sichuan, China
Fudan University Shanghai Cancer Center /Id# 210084
🇨🇳Shanghai, Shanghai, China
Zhejiang Cancer hospital /ID# 210085
🇨🇳Hangzhou, Zhejiang, China
Multiscan s.r.o. /ID# 241926
🇨🇿Praha, Czechia
APHM - Hopital Nord /ID# 209854
🇫🇷Marseille, Bouches-du-Rhone, France
CHU Lille - Hôpital Albert Calmette /ID# 205105
🇫🇷Lille, Hauts-de-France, France
Centre Hosp Intercommunal de Creteil /ID# 227108
🇫🇷Creteil, Val-de-Marne, France
CHI Toulon-La Seyne sur Mer /ID# 230545
🇫🇷Toulon, France
CHU Strasbourg - Hopital Civil /ID# 208080
🇫🇷Strasbourg cedex, France
Gemeinschaftspraxis Dr. Heinrich und Prof. Bangerter /ID# 232052
🇩🇪Augsburg, Bayern, Germany
Vivantes Klinikum Neukolln /ID# 205928
🇩🇪Berlin, Germany
Krankenhaus Martha-Maria Halle-Doelau /ID# 205442
🇩🇪Halle (Saale), Sachsen-Anhalt, Germany
Klinikum Kassel /ID# 205443
🇩🇪Kassel, Germany
Evangelisches Krankenhaus Hamm /ID# 208043
🇩🇪Hamm, Germany
Pius-Hospital Oldenburg /ID# 211615
🇩🇪Oldenburg, Germany
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 205528
🇬🇷Athens, Attiki, Greece
University General Hospital of Heraklion PA.G.N.I /ID# 205530
🇬🇷Heraklion, Kriti, Greece
Metropolitan Hospital /ID# 205529
🇬🇷Piraeus, Attiki, Greece
Euromedica General Clinic /ID# 227264
🇬🇷Thessaloniki, Greece
CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 204878
🇭🇺Encs, Borsod-Abauj-Zemplen, Hungary
Torokbalinti Tudogyogyintezet /ID# 204883
🇭🇺Torokbalint, Pest, Hungary
Matrai Gyogyintezet /ID# 204432
🇭🇺Matrahaza, Hungary
Semmelweis Egyetem /ID# 204434
🇭🇺Budapest, Hungary
Duplicate_Veszprem Megyei Tudogyogyintez /ID# 213950
🇭🇺Farkasgyepu, Hungary
Cork University Hospital /ID# 205103
🇮🇪Wilton, Cork, Ireland
Mater Misericordiae Univ Hospital /ID# 231466
🇮🇪Dublin 7, Dublin, Ireland
St James Hospital /ID# 205104
🇮🇪Dublin 8, Dublin, Ireland
Rambam Health Care Campus /ID# 204866
🇮🇱Haifa, H_efa, Israel
St Vincent's University Hospital /ID# 205102
🇮🇪Elm Park, Dublin, Ireland
Rabin Medical Center /ID# 215322
🇮🇱Haifa, H_efa, Israel
Meir Medical Center /ID# 204255
🇮🇱Kfar Saba, HaMerkaz, Israel
Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 215918
🇮🇹Rome, Roma, Italy
Soroka University Medical Center /ID# 204898
🇮🇱Be'er Sheva, HaDarom, Israel
L'Azienda Ospedaliera di Rilievo Nazionale e di Alta Specialità San Giuseppe Mos /ID# 204707
🇮🇹Avellino, Italy
Ospedale San Raffaele IRCCS /ID# 226973
🇮🇹Milan, Milano, Italy
A.O.U. San Luigi Gonzaga /ID# 204706
🇮🇹Orbassano, Torino, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 216153
🇮🇹Bologna, Italy
AOU Universita degli Studi della Campania Luigi Vanvitelli /ID# 231948
🇮🇹Napoli, Italy
Azienda Ospedaliera San Camillo Forlanini /ID# 205163
🇮🇹Rome, Roma, Italy
IRCCS Istituti Fisioterapici Ospitalieri-Istituto Nazionale Tumori Regina Elena /ID# 227011
🇮🇹Rome, Italy
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRCCS /ID# 205601
🇮🇹Meldola, Italy
Chukyo Hospital /ID# 244755
🇯🇵Nagoya-shi, Aichi, Japan
Chugoku Central Hospital /ID# 245022
🇯🇵Fukuyama-shi, Hiroshima, Japan
Himeji Medical Center /ID# 227777
🇯🇵Himeji-shi, Hyogo, Japan
Takarazuka City Hospital /ID# 245185
🇯🇵Takarazuka-shi, Hyogo, Japan
Kobe Minimally Invasive Cancer Center /ID# 248590
🇯🇵Kobe-shi, Hyogo, Japan
Okayama University Hospital /ID# 227851
🇯🇵Okayama-shi, Okayama, Japan
Kanagawa Cancer Center /ID# 205068
🇯🇵Yokohama-shi, Kanagawa, Japan
Sendai Kousei Hospital /ID# 216460
🇯🇵Sendai-shi, Miyagi, Japan
Niigata Cancer Center Hospital /ID# 216462
🇯🇵Niigata-shi, Niigata, Japan
Matsusaka Municipal Hospital /ID# 230219
🇯🇵Matsusaka-shi, Mie, Japan
Kinki-Chuo Chest Medical Center /ID# 216461
🇯🇵Sakai-shi, Osaka, Japan
Shizuoka Cancer Center /ID# 205065
🇯🇵Sunto-gun, Shizuoka, Japan
National Cancer Center Hospital /ID# 205066
🇯🇵Chuo-ku, Tokyo, Japan
The Cancer Institute Hospital Of JFCR /ID# 216463
🇯🇵Koto-ku, Tokyo, Japan
Fujieda Municipal General Hospital /ID# 248589
🇯🇵Fujieda-shi, Japan
Hiroshima Citizens Hospital /ID# 218087
🇯🇵Hiroshima-shi, Japan
Yamaguchi - Ube Medical Center /ID# 227778
🇯🇵Ube-shi, Yamaguchi, Japan
National Cancer Center /ID# 204241
🇰🇷Goyang, Gyeonggido, Korea, Republic of
Seoul National University Bundang Hospital /ID# 204237
🇰🇷Seongnam, Gyeonggido, Korea, Republic of
The Catholic University of Korea, ST. Vincent's Hospital /ID# 229647
🇰🇷Suwon, Gyeonggido, Korea, Republic of
Pusan National University Yangsan Hospital /ID# 233871
🇰🇷Yangsan-si, Gyeongsangnamdo, Korea, Republic of
Inha University Hospital /ID# 234206
🇰🇷Incheon, Korea, Republic of
Meander Medisch Centrum /ID# 217756
🇳🇱Amersfoort, Netherlands
Antoni van Leeuwenhoek /ID# 216657
🇳🇱Amsterdam, Noord-Holland, Netherlands
Chonnam National University Hwasun Hospital /ID# 206951
🇰🇷Jeonnam, Korea, Republic of
Ziekenhuis St. Jansdal /ID# 216658
🇳🇱Harderwijk, Netherlands
Asan Medical Center /ID# 204236
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center /ID# 227083
🇰🇷Seoul, Korea, Republic of
Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej /ID# 231476
🇵🇱Lodz, Lodzkie, Poland
Wojewodzki Szpital im. Sw. Ojca Pio /ID# 231960
🇵🇱Przemysl, Podkarpackie, Poland
Dom Lekarski S.A. /ID# 231479
🇵🇱Szczecin, Zachodniopomorskie, Poland
VA Caribbean Healthcare System /ID# 206336
🇵🇷San Juan, Puerto Rico
Puerto Rico Hematology Oncolog /ID# 206337
🇵🇷San Juan, Puerto Rico
S.C. Centrul de Oncologie Sf. Nectarie S.R.L. /ID# 227623
🇷🇴Craiova, Dolj, Romania
Institutul Oncologic Prof. Dr. Alexandru Trestioreanu Bucuresti /ID# 227216
🇷🇴Bucharest, Romania
Spitalul Clinic Coltea /ID# 227241
🇷🇴Bucharest, Romania
S.C. Gral Medical Srl /Id# 227215
🇷🇴Bucharest, Romania
Krasnoyarsk Regional Clinical Oncology Dispensary n.a. A.I. Kryzhanovsky /ID# 232065
🇷🇺Krasnoyarsk, Krasnoyarskiy Kray, Russian Federation
Arkhangelsk Clinical Oncology Dispensary /ID# 216418
🇷🇺Arkhangelsk, Russian Federation
Kostroma region oncology center /ID# 231317
🇷🇺Kostroma, Russian Federation
Univercity Headache Clynic,LTD /ID# 212080
🇷🇺Moscow, Russian Federation
VitaMed LLC /ID# 228957
🇷🇺Moscow, Russian Federation
National Medical Research Radiological Centre /ID# 231263
🇷🇺Obninsk, Russian Federation
Center of Palliative Medicine De Vita /ID# 212900
🇷🇺St. Petersburg, Russian Federation
Instituto Catalan de Oncologia (ICO) Badalona /ID# 216106
🇪🇸Badalona, Barcelona, Spain
Euromedservice /ID# 206390
🇷🇺Pushkin, Russian Federation
Newclinic Medical Center /ID# 216262
🇷🇺Pyatigorsk, Russian Federation
Hospital Clínico Universitario de Santiago-CHUS /ID# 204367
🇪🇸Santiago de Compostela, A Coruna, Spain
Hospital Universitario Fundacion Alcorcon /ID# 232361
🇪🇸Alcorcon, Madrid, Spain
CHU Insular-Materno Infantil /ID# 232362
🇪🇸Las Palmas de Gran Canaria, Las Palmas, Spain
Hospital Nuestra Senora de Sonsoles /ID# 232367
🇪🇸Avila, Spain
Mayo Clinic Arizona /ID# 218550
🇺🇸Phoenix, Arizona, United States
Mayo Clinic - Rochester /ID# 215603
🇺🇸Rochester, Minnesota, United States
Vanderbilt Ingram Cancer Center /ID# 203281
🇺🇸Nashville, Tennessee, United States
Mercy Research Mercy Clinic Oklahoma Communities, Inc. / OKC /ID# 230154
🇺🇸Oklahoma City, Oklahoma, United States
Providence Cancer Center Oncology and Hematology Care - Westside Portland /ID# 203301
🇺🇸Portland, Oregon, United States
Medical College of Wisconsin /ID# 210062
🇺🇸Milwaukee, Wisconsin, United States
Hospital Universitario Dexeus - Grupo Quironsalud /ID# 232368
🇪🇸Barcelona, Spain
Hospital Universitario Ramon y Cajal /ID# 203922
🇪🇸Madrid, Spain
Hospital Regional Universitario de Malaga /ID# 216081
🇪🇸Malaga, Spain
Hospital Universitario HM Sanchinarro /ID# 203913
🇪🇸Madrid, Spain
Hospital Universitario Virgen del Rocio /ID# 216058
🇪🇸Sevilla, Spain
Hospital Universitario y Politecnico La Fe /ID# 203862
🇪🇸Valencia, Spain
KSW Kantonsspital Winterthur /ID# 231284
🇨🇭Winterthur, Zuerich, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 205831
🇨🇳Kaohsiung, Taiwan
Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation /ID# 205309
🇨🇳Chia-Yi, Taiwan
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi /ID# 205243
🇹🇷Ankara, Turkey
Adana Sehir Egitim ve Arastirma Hastanesi /ID# 206000
🇹🇷Adana, Turkey
Akdeniz Universitesi Tip Fakul /ID# 205238
🇹🇷Antalya, Turkey
Trakya University Medical Facu /ID# 205242
🇹🇷Edirne, Istanbul, Turkey
Prof. Dr. Suleyman Yalcın Sehir Hastanesi /ID# 215082
🇹🇷Istanbul, Turkey
Dr. Suat Seren Gogus Has /ID# 215083
🇹🇷Izmir, Turkey
University College London Hospitals NHS Foundation Trust /ID# 231467
🇬🇧London, United Kingdom
University Hospitals Birmingham NHS Foundation Trust /ID# 206209
🇬🇧Birmingham, United Kingdom
Mayo Clinic /ID# 218488
🇺🇸Jacksonville, Florida, United States
Hospital Universitario Vall d'Hebron /ID# 206997
🇪🇸Barcelona, Spain
Univ of Colorado Cancer Center /ID# 203212
🇺🇸Aurora, Colorado, United States
University of South Alabama /ID# 212939
🇺🇸Mobile, Alabama, United States
LA Hematology-Oncology Med Group /ID# 203338
🇺🇸Orange, California, United States
Northwestern University Feinberg School of Medicine /ID# 203239
🇺🇸Chicago, Illinois, United States
Advanced Cancer Treatment Center /ID# 239565
🇺🇸Brooksville, Florida, United States
Joliet Oncology-Hematology Associates, LTD /ID# 203238
🇺🇸Joliet, Illinois, United States
Dartmouth-Hitchcock Medical Center /ID# 203350
🇺🇸Lebanon, New Hampshire, United States
Washington University-School of Medicine /ID# 203217
🇺🇸Saint Louis, Missouri, United States
Univ Hosp Cleveland /ID# 215648
🇺🇸Cleveland, Ohio, United States
Gabrail Cancer Center Research /ID# 216056
🇺🇸Canton, Ohio, United States
The Tweed Hospital /ID# 206601
🇦🇺Tweed Heads, New South Wales, Australia
Affiliated Hospital of Hebei University /ID# 227262
🇨🇳Baoding, Hebei, China
Medical Center Nadezhda /ID# 230473
🇧🇬Sofia, Bulgaria
Centre Leon Berard /ID# 205107
🇫🇷Lyon CEDEX 08, Rhone, France
Vseobecna fakultni nemocnice v Praze /ID# 229797
🇨🇿Praha, Czechia
Harbin Medical University Cancer Hospital /Id# 231573
🇨🇳Harbin, Heilongjiang, China
HCL - Hopital Louis Pradel /ID# 216209
🇫🇷Bron, Rhone, France
The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 211154
🇨🇳Hangzhou, Zhejiang, China
Universitatsklinikum Mannheim /ID# 228798
🇩🇪Mannheim, Baden-Wuerttemberg, Germany
Asklepios Fachkliniken Muenchen-Gauting /ID# 207789
🇩🇪Gauting, Germany
Universitaetsklinikum Giessen /ID# 231856
🇩🇪Gießen, Hessen, Germany
Azienda Ospedaliero-Universitaria di Parma /ID# 204983
🇮🇹Parma, Italy
Aichi Cancer Center Hospital /ID# 207790
🇯🇵Nagoya-shi, Aichi, Japan
Osaka City General Hospital /ID# 233172
🇯🇵Osaka-shi, Osaka, Japan
Chungbuk National Univ Hosp /ID# 205680
🇰🇷Cheongju, Korea, Republic of
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Bada /ID# 230595
🇵🇱Warsaw, Mazowieckie, Poland
Institutul Oncologic Prof Dr I Chiricuta /ID# 206320
🇷🇴Cluj Napoca, Romania
St. Petersburg scientific center for specialized medical care (oncological) /ID# 206405
🇷🇺Saint Petersburg, Sankt-Peterburg, Russian Federation
Universitätsspital Basel /ID# 230977
🇨🇭Basel, Basel-Stadt, Switzerland
Hospital Universitario Virgen Macarena /ID# 230998
🇪🇸Sevilla, Spain
Gazi University Medical Faculty /ID# 239816
🇹🇷Ankara, Turkey
Barts Health NHS Trust /ID# 239889
🇬🇧London, London, City Of, United Kingdom
Sutter Medical Center Sacramen /ID# 203299
🇺🇸Sacramento, California, United States
AdventHealth Cancer Institute - Orlando /ID# 239960
🇺🇸Orlando, Florida, United States
Norton Cancer Institute - St Matthews /ID# 203284
🇺🇸Louisville, Kentucky, United States
St. Lukes Cancer Institute /ID# 227697
🇺🇸Kansas City, Missouri, United States