Neural Correlates of Language Control in Bilinguals. Functional MRI and Stimulation Mapping Data in Awake Surgery. (NEUROSWITCH)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Brain activity
研究概览
简要总结
For bilingual and multilingual patients, brain activation and Electric Stimulation Mapping studies have shown that different languages may be localized, at least partially, in distinct microanatomical systems located within the same gross anatomical areas.
The present investigation involves both types of healthy bilinguals with carefully controlled proficiency levels, as well as bilingual patients suffering from low-grade glioma.
Functional magnetic resonance imaging data will be collected while the participants perform a picture naming task in blocked conditions for both languages (either English or French) or in switch condition (English and French). A stimulation mapping study will be conducted in the patients during awake surgery with the same tasks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Bilingual patients with a pathology indicating an intervention in awake surgery (e.g. low-grade glioma)
- •At least C1-level of the CECR in both languages
- •At least 12 years of schooling (French BAC)
- •Right-handed (Edinburgh test, 1971)
- •Performance indicator Eastern Cooperative Oncology Group 0-2 (cf. annexe)
- •Life expectation > 6 month
- •Affiliated to social insurance
- •Having given informed consent
- •Healthy volunteers:
- •French-English or English-French bilinguals with at least a C1 level (CECR) in both languages
- •At least 12 years of schooling (French BAC)
- •Right-handed (Edinburgh test, 1971)
- •Early bilinguals: age of acquisition of both languages < 3 years
- •Late bilinguals: age of acquisition of the L2 > 10 years
排除标准
- •Contra-indication for MRI
- •Left-handed or ambidexter (less than +80 at the Edinburgh test - 1971)
- •Mini-Mental State Examination <26
- •Patient who cannot respect the procedures, visits, exams described in the protocol
- •Any other medical or psychiatric affection which renders inclusion of the patient to the study inappropriate as judged by the principal investigator
- •Healthy volunteers:
- •Contra-indication for MRI
- •Mini-Mental State Examination < 26
- •Age of acquisition of one of the language between 3 and 10 years
研究组 & 干预措施
healthy early bilinguals
healthy early bilinguals functional magnetic resonance imaging
干预措施: functional magnetic resonance imaging (Device)
healthy late bilinguals
healthy late bilinguals functional magnetic resonance imaging
干预措施: functional magnetic resonance imaging (Device)
bilingual patients
bilingual patients suffering from low-grade glioma in the language areas functional magnetic resonance imaging
干预措施: functional magnetic resonance imaging (Device)
结局指标
主要结局
Brain activity
时间窗: 24 hours
The primary judgment criteria is brain activity as measured by functional magnetic resonance imaging : * In blocked vs. switched naming in control subjects * In switched naming in early vs. late bilingual subjects * In blocked vs. switched naming in early vs. late bilingual subjects
次要结局
- Brain activity(24 hours)