Neural Correlates of Language Control in Bilinguals. Functional MRI and Stimulation Mapping Data in Awake Surgery.
- Conditions
- Bilingualism
- Interventions
- Device: functional magnetic resonance imaging
- Registration Number
- NCT02391493
- Lead Sponsor
- University Hospital, Toulouse
- Brief Summary
For bilingual and multilingual patients, brain activation and Electric Stimulation Mapping studies have shown that different languages may be localized, at least partially, in distinct microanatomical systems located within the same gross anatomical areas.
The present investigation involves both types of healthy bilinguals with carefully controlled proficiency levels, as well as bilingual patients suffering from low-grade glioma.
Functional magnetic resonance imaging data will be collected while the participants perform a picture naming task in blocked conditions for both languages (either English or French) or in switch condition (English and French). A stimulation mapping study will be conducted in the patients during awake surgery with the same tasks.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
Patients:
- Bilingual patients with a pathology indicating an intervention in awake surgery (e.g. low-grade glioma)
- At least C1-level of the CECR in both languages
- At least 12 years of schooling (French BAC)
- Right-handed (Edinburgh test, 1971)
- Performance indicator Eastern Cooperative Oncology Group 0-2 (cf. annexe)
- Life expectation > 6 month
- Affiliated to social insurance
- Having given informed consent
Healthy volunteers:
- French-English or English-French bilinguals with at least a C1 level (CECR) in both languages
- At least 12 years of schooling (French BAC)
- Right-handed (Edinburgh test, 1971)
- Early bilinguals: age of acquisition of both languages < 3 years
- Late bilinguals: age of acquisition of the L2 > 10 years
Patients:
- Contra-indication for MRI
- Left-handed or ambidexter (less than +80 at the Edinburgh test - 1971)
- Mini-Mental State Examination <26
- Patient who cannot respect the procedures, visits, exams described in the protocol
- Any other medical or psychiatric affection which renders inclusion of the patient to the study inappropriate as judged by the principal investigator
Healthy volunteers:
- Contra-indication for MRI
- Mini-Mental State Examination < 26
- Age of acquisition of one of the language between 3 and 10 years
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description healthy early bilinguals functional magnetic resonance imaging healthy early bilinguals functional magnetic resonance imaging bilingual patients functional magnetic resonance imaging bilingual patients suffering from low-grade glioma in the language areas functional magnetic resonance imaging healthy late bilinguals functional magnetic resonance imaging healthy late bilinguals functional magnetic resonance imaging
- Primary Outcome Measures
Name Time Method Brain activity 24 hours The primary judgment criteria is brain activity as measured by functional magnetic resonance imaging :
* In blocked vs. switched naming in control subjects
* In switched naming in early vs. late bilingual subjects
* In blocked vs. switched naming in early vs. late bilingual subjects
- Secondary Outcome Measures
Name Time Method Brain activity 24 hours The secondary judgment criteria is brain activity measured by functional magnetic resonance imaging :
* In blocked vs. switched naming in the patients
* In French vs. English and English vs. French naming in the late bilinguals
* In French vs. English and English vs. French naming in the early bilinguals
* In French vs. LX and LX vs. French naming in the patients.
Trial Locations
- Locations (1)
University Hospital of Toulouse
🇫🇷Toulouse, France